Safety Profile
Known Safety Concerns
- Sodium content relevant for low-sodium diets -- hypertension, heart failure
- GI distress at high doses of vitamin C equivalent
- Kidney stone risk in predisposed individuals at high doses
- Monitor total sodium intake when combining with other sodium-containing supplements
Contraindications
- Sodium content relevant for low-sodium diets -- hypertension, heart failure
- GI distress at high doses of vitamin C equivalent
Interactions
Information not yet available for this ingredient profile.
Evidence and Scientific Findings
Ingredient Overview
Sodium ascorbate is a buffered form of vitamin C that is less acidic than ascorbic acid. The sodium content (approximately 131 mg sodium per 1,000 mg vitamin C) is relevant for individuals on sodium-restricted diets, such as those with hypertension or heart failure. Otherwise the safety profile mirrors ascorbic acid.
Biological and Chemical Classification
- Scientific Name
- Sodium L-ascorbate
Mechanism of Action
Information not yet available for this ingredient profile.
Clinical Evidence of Effectiveness
Information not yet available for this ingredient profile.
Pharmacokinetics
Information not yet available for this ingredient profile.
Recommended Dosage
Information not yet available for this ingredient profile.
SETI — Scientific Evidence Transparency Index
Executive Summary — Ingredient Assessment
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or RCT)
- Main clinical benefit observed: Vitamin
- Evidence consistency: High consistency across studies (100%)
- Sodium content relevant for low-sodium diets -- hypertension, heart failure
- GI distress at high doses of vitamin C equivalent
- Kidney stone risk in predisposed individuals at high doses
- Monitor total sodium intake when combining with other sodium-containing supplements
The available scientific evidence for Vitamin C (Sodium Ascorbate) indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.
Total SETI Score
High risk| Evidence quality | 10/40 |
| Evidence consistency | 20/20 |
| Safety signals | 0/20 |
| Study recency | 10/10 |
| Evidence transparency | 10/10 |
Evidence Summary
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or systematic review)
- 0 studies identified benefits or no safety concern (GREEN)
- 10 studies reported limited or advisory safety evidence (YELLOW)
Evidence Policy
Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.
Last updated: 24 მარ 2026, 07:53
Evidence Distribution
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Observational / other LOW evidence YELLOWAscorbate-enabled C-H bond amination catalyzed by myoglobin reconstituted with a trifluoromethyl-substituted Iron porphyrin. ↗Sonoda C et al.. Ascorbate-enabled C-H bond amination catalyzed by myoglobin reconstituted with a trifluoromethyl-substituted Iron porphyrin.. J Inorg Biochem. 2026. PMID:41494238.PMID 41494238 ↗Journal J Inorg BiochemYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41494238/
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Observational / other LOW evidence YELLOWMetabolomic Profiling and Characterization of a Novel 3D Culture System for Studying Chondrocyte Mechanotransduction. ↗Brahmachary PP et al.. Metabolomic Profiling and Characterization of a Novel 3D Culture System for Studying Chondrocyte Mechanotransduction.. Cell Mol Bioeng. 2025. PMID:41328310.PMID 41328310 ↗Journal Cell Mol BioengYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41328310/
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Observational / other LOW evidence YELLOWImpact of the Use of 2-Phospho-L Ascorbic Acid in the Production of Engineered Stromal Tissue for Regenerative Medicine. ↗Brownell D et al.. Impact of the Use of 2-Phospho-L Ascorbic Acid in the Production of Engineered Stromal Tissue for Regenerative Medicine.. Cells. 2025. PMID:40710376.PMID 40710376 ↗Journal CellsYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40710376/
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Observational / other LOW evidence YELLOWMetabolomic Profiling and Characterization of a Novel 3D Culture System for Studying Chondrocyte Mechanotransduction. ↗Brahmachary PP et al.. Metabolomic Profiling and Characterization of a Novel 3D Culture System for Studying Chondrocyte Mechanotransduction.. bioRxiv. 2025. PMID:38915493.PMID 38915493 ↗Journal bioRxivYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/38915493/
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Observational / other LOW evidence YELLOWLong-Term Storage of Ti(3)C(2)T(x) Aqueous Dispersion with Stable Electrochemical Properties. ↗Peng T et al.. Long-Term Storage of Ti(3)C(2)T(x) Aqueous Dispersion with Stable Electrochemical Properties.. Materials (Basel). 2024. PMID:39597238.PMID 39597238 ↗Journal Materials (Basel)Year 2024Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/39597238/
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Observational / other LOW evidence YELLOWLess is More: Underlying Mechanism of Zn Electrode Long-Term Stability using Sodium L-Ascorbate as Electrolyte Additive. ↗Luo Y et al.. Less is More: Underlying Mechanism of Zn Electrode Long-Term Stability using Sodium L-Ascorbate as Electrolyte Additive.. Small. 2024. PMID:38282374.PMID 38282374 ↗Journal SmallYear 2024Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/38282374/
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Observational / other LOW evidence YELLOWCarotenoid-dependent singlet oxygen photogeneration in light-harvesting complex 2 of Ectothiorhodospira haloalkaliphila leads to the formation of organic hydroperoxides and damage to both… ↗Yanykin D et al.. Carotenoid-dependent singlet oxygen photogeneration in light-harvesting complex 2 of Ectothiorhodospira haloalkaliphila leads to the formation of organic hydroperoxides and damage to both pigments and protein matrix.. PeerJ. 2024. PMID:38250719.PMID 38250719 ↗Journal PeerJYear 2024Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/38250719/
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Observational / other LOW evidence YELLOWA highly selective and sensitive fluorescence probe for dopamine determination based on a bisquinoline-substituted calix[4]arene carboxylic acid derivative. ↗Sayin S. A highly selective and sensitive fluorescence probe for dopamine determination based on a bisquinoline-substituted calix[4]arene carboxylic acid derivative.. J Biomol Struct Dyn. 2024. PMID:37938142.PMID 37938142 ↗Journal J Biomol Struct DynYear 2024Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/37938142/
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Observational / other LOW evidence YELLOWAzide-Assisted Growth of Copper Nanostructures and Their Application as a Carbon Supported Catalyst in Two-Step Three-Component Azide-Alkyne Cycloadditions. ↗Roemer M et al.. Azide-Assisted Growth of Copper Nanostructures and Their Application as a Carbon Supported Catalyst in Two-Step Three-Component Azide-Alkyne Cycloadditions.. Langmuir. 2023. PMID:37585437.PMID 37585437 ↗Journal LangmuirYear 2023Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/37585437/
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Observational / other LOW evidence YELLOWDevelopment of Highly Sensitive and Humidity Independent Room Temeprature NO(2) Gas Sensor Using Two Dimensional Ti(3)C(2)T(x) Nanosheets and One Dimensional WO(3) Nanorods… ↗Gasso S et al.. Development of Highly Sensitive and Humidity Independent Room Temeprature NO(2) Gas Sensor Using Two Dimensional Ti(3)C(2)T(x) Nanosheets and One Dimensional WO(3) Nanorods Nanocomposite.. ACS Sens. 2022. PMID:35944209.PMID 35944209 ↗Journal ACS SensYear 2022Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/35944209/
Score Transparency
0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.
Method: Q = number of approved references ÷ 10 (capped at 1.0)
Limited — mostly case reports or animal studies
Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.
Mixed or neutral — roughly equal benefit and risk signals
Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.
One or more monitoring-level safety signals active
Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.
Final GIRI Score for Vitamin C (Sodium Ascorbate). Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
Full methodology & data sources
The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.
- References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
- Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
- Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
- Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
Risk Level Classification
Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.
0–3.0
3.0–5.5
5.5–7.5
7.5–10
The score pin shows exactly where this ingredient falls on the fixed risk scale.
What drove the Low classification for Vitamin C (Sodium Ascorbate)
A score of 2.0 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
0 approved references.
Limited — mostly case reports or animal studies (Level 4–5).
Neutral or mixed — benefit and risk signals roughly balanced.
No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.
No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).
How are the Low / Moderate / High / Critical thresholds defined?
The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:
| Level | Score | Meaning |
|---|---|---|
| LOW | 0.0 – 2.9 | Sparse or predominantly beneficial evidence. No active safety alerts. |
| MODERATE | 3.0 – 5.4 | Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups. |
| HIGH | 5.5 – 7.4 | Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended. |
| CRITICAL | 7.5 – 10 | Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision. |
Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.