ხუთშაბათი, აპრილი 16, 2026
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Global Ingredient Risk Index Immune Support

Turkey Tail Mushroom Extract

Trametes versicolor

Also known as: Coriolus versicolor, PSK, PSP, Yun Zhi

LOW RISK 2.0/10 How?

This ingredient is classified as unclassified risk (GIRI score: 2.0/10).

02

Safety Profile

Information not yet available for this ingredient profile.

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03

Interactions

Information not yet available for this ingredient profile.

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04

Evidence and Scientific Findings

Overview

Ingredient Overview

Turkey Tail is a medicinal mushroom used for immune modulation and studied as an adjunct in oncology. It is generally well tolerated. GI side effects and darkening of finger nails have been reported. May interact with immunosuppressant drugs. Avoid in individuals with mushroom allergies or transplant patients on immunosuppressants.

Classification

Biological and Chemical Classification

Scientific Name
Trametes versicolor
Mechanism

Mechanism of Action

Information not yet available for this ingredient profile.

Clinical Evidence

Clinical Evidence of Effectiveness

Information not yet available for this ingredient profile.

Pharmacokinetics

Pharmacokinetics

Information not yet available for this ingredient profile.

Dosage

Recommended Dosage

Information not yet available for this ingredient profile.

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05

SETI — Scientific Evidence Transparency Index

SETI Score 50/100
Risk Level High risk
Scientific Confidence Low
Evidence Strength Limited
Key Benefit Immune Support
Evidence Reviewed 10 PubMed studies
Scientific Confidence Low
Based on study quality, consistency, and recency

Executive Summary — Ingredient Assessment

SETI Score 50/100
Risk Level High risk
Evidence Strength Limited
Main Benefit Immune Support
Ingredient Turkey Tail Mushroom Extract
Scientific name Trametes versicolor
Scientific Evidence Overview
  • 10 studies reviewed
  • 0 high-quality studies (meta-analysis or RCT)
  • Main clinical benefit observed: Immune Support
  • Evidence consistency: High consistency across studies (100%)
Safety Signals
  • No significant safety signals identified in the reviewed literature.
Evidence Strength Limited
Final Scientific Assessment

The available scientific evidence for Turkey Tail Mushroom Extract indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.

Ingredient Turkey Tail Mushroom Extract
Evidence reviewed 10 peer-reviewed studies (last 10 years)
Scientific name Trametes versicolor
50 /100

Total SETI Score

High risk
Evidence quality 10/40
Evidence consistency 20/20
Safety signals 0/20
Study recency 10/10
Evidence transparency 10/10

Evidence Summary

  • 10 studies reviewed
  • 0 high-quality studies (meta-analysis or systematic review)
  • 0 studies identified benefits or no safety concern (GREEN)
  • 10 studies reported limited or advisory safety evidence (YELLOW)

Evidence Policy

Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.

Last updated: 26 მარ 2026, 14:01

Evidence Distribution

10 Other / unclassified
  1. Observational / other LOW evidence YELLOW
    Magic Mushrooms? White-Rot Fungal Degradation of Psychoactive Pharmaceuticals in Biosolids. ↗
    PMID 41867299 ↗
    Journal ACS Environ Au
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41867299/
    Burgener K et al.. Magic Mushrooms? White-Rot Fungal Degradation of Psychoactive Pharmaceuticals in Biosolids.. ACS Environ Au. 2026. PMID:41867299.
  2. Observational / other LOW evidence YELLOW
    Fungal removal of OPFRs from urban wastewater in a rotary drum bioreactor. ↗
    PMID 41846127 ↗
    Journal J Hazard Mater
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41846127/
    Losantos D et al.. Fungal removal of OPFRs from urban wastewater in a rotary drum bioreactor.. J Hazard Mater. 2026. PMID:41846127.
  3. Observational / other LOW evidence YELLOW
    The Potential of Size-Exclusion Chromatography for Evaluating the Suitability of Hydrophilic Extracts in Wood Preservation. ↗
    PMID 41829273 ↗
    Journal Polymers (Basel)
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41829273/
    Oberle A et al.. The Potential of Size-Exclusion Chromatography for Evaluating the Suitability of Hydrophilic Extracts in Wood Preservation.. Polymers (Basel). 2026. PMID:41829273.
  4. Observational / other LOW evidence YELLOW
    Trametes versicolor mycelium fermenting whole kidney beans into tempeh-like product. ↗
    PMID 41806721 ↗
    Journal Int J Food Microbiol
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41806721/
    Li X et al.. Trametes versicolor mycelium fermenting whole kidney beans into tempeh-like product.. Int J Food Microbiol. 2026. PMID:41806721.
  5. Observational / other LOW evidence YELLOW
    Clinical evidence on a Coriolus versicolor-based vaginal gel for HPV-related cervical disease: a narrative review. ↗
    PMID 41797457 ↗
    Journal Chin Clin Oncol
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41797457/
    Su00e1nchez Du00edaz E et al.. Clinical evidence on a Coriolus versicolor-based vaginal gel for HPV-related cervical disease: a narrative review.. Chin Clin Oncol. 2026. PMID:41797457.
  6. Observational / other LOW evidence YELLOW
    Nutritional, Anti-inflammatory, and in-silico inhibitory Studies of Trametes versicolor (L.) Lloyd and Flammulina velutipes (Curtis) on HER2 breast cancer protein. ↗
    PMID 41769067 ↗
    Journal Biochem Biophys Rep
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41769067/
    Iyekekpolor OM et al.. Nutritional, Anti-inflammatory, and in-silico inhibitory Studies of Trametes versicolor (L.) Lloyd and Flammulina velutipes (Curtis) on HER2 breast cancer protein.. Biochem Biophys Rep. 2026. PMID:41769067.
  7. Observational / other LOW evidence YELLOW
    Immobilization of Trametes versicolor Laccase Enzyme to Cu-silica Aerogel and its Decolorization of Synthetic Dyes. ↗
    PMID 41762358 ↗
    Journal Appl Biochem Biotechnol
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41762358/
    Isik S et al.. Immobilization of Trametes versicolor Laccase Enzyme to Cu-silica Aerogel and its Decolorization of Synthetic Dyes.. Appl Biochem Biotechnol. 2026. PMID:41762358.
  8. Observational / other LOW evidence YELLOW
    Laccase Immobilization on Carbon-Based Materials Derived from Spent Brewery Grains: Optimization and Stability Evaluation. ↗
    PMID 41752515 ↗
    Journal Molecules
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41752515/
    Almeida u00c2 et al.. Laccase Immobilization on Carbon-Based Materials Derived from Spent Brewery Grains: Optimization and Stability Evaluation.. Molecules. 2026. PMID:41752515.
  9. Observational / other LOW evidence YELLOW
    Fungal enzyme-driven precipitation polymerization: Trapping estrogenic chemicals to block vegetable contamination. ↗
    PMID 41720027 ↗
    Journal J Hazard Mater
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41720027/
    Yin Q et al.. Fungal enzyme-driven precipitation polymerization: Trapping estrogenic chemicals to block vegetable contamination.. J Hazard Mater. 2026. PMID:41720027.
  10. Observational / other LOW evidence YELLOW
    Fungal extracts influence lifespan and immune responses in the Carniolan honey bee (Apis mellifera carnica, Pollmann 1879). ↗
    PMID 41714705 ↗
    Journal Sci Rep
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41714705/
    Ansaloni LS et al.. Fungal extracts influence lifespan and immune responses in the Carniolan honey bee (Apis mellifera carnica, Pollmann 1879).. Sci Rep. 2026. PMID:41714705.
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06

Score Transparency

Q × L × D × S × 10 = 2.0 / 10

The GIRI Score is the product of four independently computed evidence components, each normalised to 0–1, then scaled to 0–10. Every component is derived exclusively from peer-reviewed references and regulatory data — no editorial judgement is applied.

Q
Evidence Quantity 0 / 10
0%

0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.

Method: Q = number of approved references ÷ 10 (capped at 1.0)

L
Evidence Quality 5 / 10
50%

Limited — mostly case reports or animal studies

Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.

D
Evidence Direction 5 / 10
Benefit
Risk
50%

Mixed or neutral — roughly equal benefit and risk signals

Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.

S
Safety Signals 5 / 10
50%

One or more monitoring-level safety signals active

Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.

0Q × 5L × 5D × 5S = 2.0 / 10

Final GIRI Score for Turkey Tail Mushroom Extract. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

Full methodology & data sources

The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.

  • References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
  • Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
  • Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
  • Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
07

Risk Level Classification

LOW RISK 2.0/10

Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.

LOW
0–3.0
MODERATE
3.0–5.5
HIGH
5.5–7.5
CRITICAL
7.5–10
2.0

The score pin shows exactly where this ingredient falls on the fixed risk scale.

What drove the Low classification for Turkey Tail Mushroom Extract

GIRI Score 2.0 / 10

A score of 2.0 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

Evidence Quantity (Q) 0 / 10 refs

0 approved references.

Evidence Quality (L) 50%

Limited — mostly case reports or animal studies (Level 4–5).

Evidence Direction (D) 50% toward risk

Neutral or mixed — benefit and risk signals roughly balanced.

Safety Signals (S) 0 active signals

No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.

Regulatory Status No restrictions found

No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).

How are the Low / Moderate / High / Critical thresholds defined?

The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:

LevelScoreMeaning
LOW0.0 – 2.9Sparse or predominantly beneficial evidence. No active safety alerts.
MODERATE3.0 – 5.4Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups.
HIGH5.5 – 7.4Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended.
CRITICAL7.5 – 10Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision.

Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.

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