ოთხშაბათი, აპრილი 15, 2026
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Global Ingredient Risk Index Botanical

Thyme Herb

Thymus vulgaris

Also known as: Thyme extract, Thymus vulgaris extract, Thyme herb extract, Thymol carvacrol extract, Garden thyme

LOW RISK 1.5/10 How?

This ingredient is classified as unclassified risk.

02

Safety Profile

Information not yet available for this ingredient profile.

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03

Interactions

Information not yet available for this ingredient profile.

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04

Evidence and Scientific Findings

Overview

Ingredient Overview

Thyme (Thymus vulgaris) herb extract standardised for thymol and carvacrol is used as an expectorant and for respiratory tract infections. It has a long history of safe traditional use and is supported by clinical data as a monotherapy and in combination with ivy leaf for acute bronchitis. Generally very well tolerated. High doses of thymol can cause GI irritation. Avoid concentrated essential oil form internally. Standard dry extract supplements are safe at recommended doses.

Classification

Biological and Chemical Classification

Scientific Name
Thymus vulgaris
Mechanism

Mechanism of Action

Information not yet available for this ingredient profile.

Clinical Evidence

Clinical Evidence of Effectiveness

Information not yet available for this ingredient profile.

Pharmacokinetics

Pharmacokinetics

Information not yet available for this ingredient profile.

Dosage

Recommended Dosage

Information not yet available for this ingredient profile.

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05

SETI — Scientific Evidence Transparency Index

SETI Score 50/100
Risk Level High risk
Scientific Confidence Low
Evidence Strength Limited
Key Benefit Botanical
Evidence Reviewed 10 PubMed studies
Scientific Confidence Low
Based on study quality, consistency, and recency

Executive Summary — Ingredient Assessment

SETI Score 50/100
Risk Level High risk
Evidence Strength Limited
Main Benefit Botanical
Ingredient Thyme Herb
Scientific name Thymus vulgaris
Scientific Evidence Overview
  • 10 studies reviewed
  • 0 high-quality studies (meta-analysis or RCT)
  • Main clinical benefit observed: Botanical
  • Evidence consistency: High consistency across studies (100%)
Safety Signals
  • No significant safety signals identified in the reviewed literature.
Evidence Strength Limited
Final Scientific Assessment

The available scientific evidence for Thyme Herb indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.

Ingredient Thyme Herb
Evidence reviewed 10 peer-reviewed studies (last 10 years)
Scientific name Thymus vulgaris
50 /100

Total SETI Score

High risk
Evidence quality 10/40
Evidence consistency 20/20
Safety signals 0/20
Study recency 10/10
Evidence transparency 10/10

Evidence Summary

  • 10 studies reviewed
  • 0 high-quality studies (meta-analysis or systematic review)
  • 0 studies identified benefits or no safety concern (GREEN)
  • 10 studies reported limited or advisory safety evidence (YELLOW)

Evidence Policy

Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.

Last updated: 06 აპრ 2026, 12:10

Evidence Distribution

10 Other / unclassified
  1. Observational / other LOW evidence YELLOW
    The Influence of Biological Measures on Strawberry Plant Growth, Yield, and Fruit Quality. ↗
    PMID 41901448 ↗
    Journal Plants (Basel)
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41901448/
    Rasiukeviu010diu016btu0117 N et al.. The Influence of Biological Measures on Strawberry Plant Growth, Yield, and Fruit Quality.. Plants (Basel). 2026. PMID:41901448.
  2. Observational / other LOW evidence YELLOW
    Optimization of Thyme, Cinnamon, and Black Seed Oil Combinations for Enhanced Antibacterial and Antioxidant Efficacy: Mixture Design and In Silico Insights. ↗
    PMID 41901219 ↗
    Journal Pharmaceuticals (Basel)
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41901219/
    Maher MS et al.. Optimization of Thyme, Cinnamon, and Black Seed Oil Combinations for Enhanced Antibacterial and Antioxidant Efficacy: Mixture Design and In Silico Insights.. Pharmaceuticals (Basel). 2026. PMID:41901219.
  3. Observational / other LOW evidence YELLOW
    Synergistic and Additive Interactions in Essential Oils Obtained from Combined Plant Materials: Enhanced Control of Insect Pests. ↗
    PMID 41900044 ↗
    Journal Molecules
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41900044/
    Hamdeni I et al.. Synergistic and Additive Interactions in Essential Oils Obtained from Combined Plant Materials: Enhanced Control of Insect Pests.. Molecules. 2026. PMID:41900044.
  4. Observational / other LOW evidence YELLOW
    Essential Oils From Lamiaceae and Myrtaceae Families: Chemical, Antifungal, Antioxidant, and Multivariate Analysis for Multifunctional Purposes. ↗
    PMID 41852145 ↗
    Journal Chem Biodivers
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41852145/
    Hamdeni I et al.. Essential Oils From Lamiaceae and Myrtaceae Families: Chemical, Antifungal, Antioxidant, and Multivariate Analysis for Multifunctional Purposes.. Chem Biodivers. 2026. PMID:41852145.
  5. Observational / other LOW evidence YELLOW
    Chitosan/Tripolyphosphate Nanoparticles Encapsulating Essential Oils as a New Class of Biopesticides: Structural Properties and Ecotoxicity Evaluation. ↗
    PMID 41826249 ↗
    Journal Environ Toxicol
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41826249/
    Machado S et al.. Chitosan/Tripolyphosphate Nanoparticles Encapsulating Essential Oils as a New Class of Biopesticides: Structural Properties and Ecotoxicity Evaluation.. Environ Toxicol. 2026. PMID:41826249.
  6. Observational / other LOW evidence YELLOW
    Ethnopharmocological study of medicinal plants used for treatment of skin diseases by herbalists in Northwestern region of Algeria. ↗
    PMID 41758749 ↗
    Journal PLoS One
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41758749/
    Hantour R et al.. Ethnopharmocological study of medicinal plants used for treatment of skin diseases by herbalists in Northwestern region of Algeria.. PLoS One. 2026. PMID:41758749.
  7. Observational / other LOW evidence YELLOW
    Susceptibility of Cooking Herbs to Stored-Product Moths. ↗
    PMID 41752543 ↗
    Journal Insects
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41752543/
    Malabusini S et al.. Susceptibility of Cooking Herbs to Stored-Product Moths.. Insects. 2026. PMID:41752543.
  8. Observational / other LOW evidence YELLOW
    In Vitro Assessment of Essential Oils as Sustainable Antifungal Agents Against Sclerotinia sclerotiorum Causing Lettuce Drop. ↗
    PMID 41752459 ↗
    Journal Molecules
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41752459/
    Tunu00e7 M et al.. In Vitro Assessment of Essential Oils as Sustainable Antifungal Agents Against Sclerotinia sclerotiorum Causing Lettuce Drop.. Molecules. 2026. PMID:41752459.
  9. Observational / other LOW evidence YELLOW
    Phytochemicals as inhibitors of pathogenesis to combat ostertagiosis, toxocariasis, trichostrongylosis and trichuriasis in cattle: A systematic review. ↗
    PMID 41747782 ↗
    Journal Microb Pathog
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41747782/
    Hayat H et al.. Phytochemicals as inhibitors of pathogenesis to combat ostertagiosis, toxocariasis, trichostrongylosis and trichuriasis in cattle: A systematic review.. Microb Pathog. 2026. PMID:41747782.
  10. Observational / other LOW evidence YELLOW
    Anti-malarial evaluation of some bioactive plant compounds: An integrated computational approach combining QSAR and molecular docking. ↗
    PMID 41720063 ↗
    Journal Comput Biol Chem
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41720063/
    Otmanine K et al.. Anti-malarial evaluation of some bioactive plant compounds: An integrated computational approach combining QSAR and molecular docking.. Comput Biol Chem. 2026. PMID:41720063.
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06

Score Transparency

Q × L × D × S × 10 = 1.5 / 10

The GIRI Score is the product of four independently computed evidence components, each normalised to 0–1, then scaled to 0–10. Every component is derived exclusively from peer-reviewed references and regulatory data — no editorial judgement is applied.

Q
Evidence Quantity 0 / 10
0%

0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.

Method: Q = number of approved references ÷ 10 (capped at 1.0)

L
Evidence Quality 5 / 10
50%

Limited — mostly case reports or animal studies

Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.

D
Evidence Direction 5 / 10
Benefit
Risk
50%

Mixed or neutral — roughly equal benefit and risk signals

Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.

S
Safety Signals 5 / 10
50%

One or more monitoring-level safety signals active

Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.

0Q × 5L × 5D × 5S = 1.5 / 10

Final GIRI Score for Thyme Herb. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

Full methodology & data sources

The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.

  • References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
  • Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
  • Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
  • Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
07

Risk Level Classification

LOW RISK 1.5/10

Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.

LOW
0–3.0
MODERATE
3.0–5.5
HIGH
5.5–7.5
CRITICAL
7.5–10
1.5

The score pin shows exactly where this ingredient falls on the fixed risk scale.

What drove the Low classification for Thyme Herb

GIRI Score 1.5 / 10

A score of 1.5 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

Evidence Quantity (Q) 0 / 10 refs

0 approved references.

Evidence Quality (L) 50%

Limited — mostly case reports or animal studies (Level 4–5).

Evidence Direction (D) 50% toward risk

Neutral or mixed — benefit and risk signals roughly balanced.

Safety Signals (S) 0 active signals

No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.

Regulatory Status No restrictions found

No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).

How are the Low / Moderate / High / Critical thresholds defined?

The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:

LevelScoreMeaning
LOW0.0 – 2.9Sparse or predominantly beneficial evidence. No active safety alerts.
MODERATE3.0 – 5.4Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups.
HIGH5.5 – 7.4Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended.
CRITICAL7.5 – 10Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision.

Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.

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