Safety Profile
Information not yet available for this ingredient profile.
Interactions
Information not yet available for this ingredient profile.
Evidence and Scientific Findings
Ingredient Overview
Sulforaphane glucosinolate (SGS) is a stable precursor to sulforaphane found in broccoli seed extract. It activates Nrf2 antioxidant pathways. It is generally well tolerated. High doses may affect thyroid iodine uptake in iodine-deficient individuals. It may interfere with the absorption of some thyroid medications. GI discomfort is possible at high doses. Very safe at standard supplement doses.
Biological and Chemical Classification
- Scientific Name
- Brassica oleracea
Mechanism of Action
Information not yet available for this ingredient profile.
Clinical Evidence of Effectiveness
Information not yet available for this ingredient profile.
Pharmacokinetics
Information not yet available for this ingredient profile.
Recommended Dosage
Information not yet available for this ingredient profile.
SETI — Scientific Evidence Transparency Index
Executive Summary — Ingredient Assessment
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or RCT)
- Main clinical benefit observed: Specialty
- Evidence consistency: High consistency across studies (100%)
- No significant safety signals identified in the reviewed literature.
The available scientific evidence for Sulforaphane Glucosinolate indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.
Total SETI Score
High risk| Evidence quality | 10/40 |
| Evidence consistency | 20/20 |
| Safety signals | 0/20 |
| Study recency | 8/10 |
| Evidence transparency | 8/10 |
Evidence Summary
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or systematic review)
- 0 studies identified benefits or no safety concern (GREEN)
- 10 studies reported limited or advisory safety evidence (YELLOW)
Evidence Policy
Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.
Last updated: 26 მარ 2026, 14:10
Evidence Distribution
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Observational / other LOW evidence YELLOWPotent antioxidant and anticancer efficacy of Brassica oleracea var acephala extracts: a cytomorphological and antidiabetic assessment. ↗Shafi S et al.. Potent antioxidant and anticancer efficacy of Brassica oleracea var acephala extracts: a cytomorphological and antidiabetic assessment.. Braz J Biol. 2026. PMID:41880462.PMID 41880462 ↗Journal Braz J BiolYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41880462/
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Observational / other LOW evidence YELLOWBnaPAP2.C2 plays a novel inhibitory role in anthocyanin accumulation compared to its paralogs in rapeseed (Brassica napus L.). ↗Xu L et al.. BnaPAP2.C2 plays a novel inhibitory role in anthocyanin accumulation compared to its paralogs in rapeseed (Brassica napus L.).. Plant J. 2026. PMID:41877443.PMID 41877443 ↗Journal Plant JYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41877443/
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Observational / other LOW evidence YELLOWA spatiotemporal resolution to genetic redundancy: MIR164 diversification coordinates development and metabolism in Brassica. ↗Chen X et al.. A spatiotemporal resolution to genetic redundancy: MIR164 diversification coordinates development and metabolism in Brassica.. Plant J. 2026. PMID:41867071.PMID 41867071 ↗Journal Plant JYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41867071/
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Observational / other LOW evidence YELLOWIdentification of Brassica oleracea germplasm resources resistant to Plutella xylostella (L.). ↗Li P et al.. Identification of Brassica oleracea germplasm resources resistant to Plutella xylostella (L.).. Pest Manag Sci. 2026. PMID:41859830.PMID 41859830 ↗Journal Pest Manag SciYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41859830/
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Observational / other LOW evidence YELLOWBrassica metabolite priming boosts growth and ion-water homeostasis under salt stress in broccoli. ↗Albaladejo-Marico L et al.. Brassica metabolite priming boosts growth and ion-water homeostasis under salt stress in broccoli.. J Plant Physiol. 2026. PMID:41855887.PMID 41855887 ↗Journal J Plant PhysiolYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41855887/
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Observational / other LOW evidence YELLOWFunctional characterization of BoVML1 uncovers a RER3-related network controlling chloroplast development and leaf morphogenesis in cabbage. ↗Chen G et al.. Functional characterization of BoVML1 uncovers a RER3-related network controlling chloroplast development and leaf morphogenesis in cabbage.. Plant Physiol Biochem. 2026. PMID:41844484.PMID 41844484 ↗Journal Plant Physiol BiochemYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41844484/
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Observational / other LOW evidence YELLOWBroccoli-mediated gold nanoparticles: Eco-friendly synthesis and nano-bio interactions promoting wound healing and targeted cytotoxicity. ↗Taay YM et al.. Broccoli-mediated gold nanoparticles: Eco-friendly synthesis and nano-bio interactions promoting wound healing and targeted cytotoxicity.. J Genet Eng Biotechnol. 2026. PMID:41839661.PMID 41839661 ↗Journal J Genet Eng BiotechnolYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41839661/
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Observational / other LOW evidence YELLOWHerbicidal Activity of the Invasive Weed Malachra capitata L.: Growth Stage Dependence, Bioassay-Guided Fractionation, and Physiological Effects on Seed Germination. ↗Wichittrakarn P et al.. Herbicidal Activity of the Invasive Weed Malachra capitata L.: Growth Stage Dependence, Bioassay-Guided Fractionation, and Physiological Effects on Seed Germination.. Plants (Basel). 2026. PMID:41829862.PMID 41829862 ↗Journal Plants (Basel)Year 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41829862/
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Observational / other LOW evidence YELLOWBroccoli. ↗Broccoli.. 2006. PMID:41855365.PMID 41855365 ↗Year 2006Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41855365/
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Observational / other LOW evidence YELLOWCabbage. ↗Cabbage.. 2006. PMID:30000833.PMID 30000833 ↗Year 2006Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/30000833/
Score Transparency
0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.
Method: Q = number of approved references ÷ 10 (capped at 1.0)
Limited — mostly case reports or animal studies
Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.
Mixed or neutral — roughly equal benefit and risk signals
Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.
One or more monitoring-level safety signals active
Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.
Final GIRI Score for Sulforaphane Glucosinolate. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
Full methodology & data sources
The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.
- References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
- Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
- Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
- Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
Risk Level Classification
Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.
0–3.0
3.0–5.5
5.5–7.5
7.5–10
The score pin shows exactly where this ingredient falls on the fixed risk scale.
What drove the Low classification for Sulforaphane Glucosinolate
A score of 1.5 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
0 approved references.
Limited — mostly case reports or animal studies (Level 4–5).
Neutral or mixed — benefit and risk signals roughly balanced.
No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.
No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).
How are the Low / Moderate / High / Critical thresholds defined?
The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:
| Level | Score | Meaning |
|---|---|---|
| LOW | 0.0 – 2.9 | Sparse or predominantly beneficial evidence. No active safety alerts. |
| MODERATE | 3.0 – 5.4 | Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups. |
| HIGH | 5.5 – 7.4 | Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended. |
| CRITICAL | 7.5 – 10 | Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision. |
Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.