Safety Profile
Information not yet available for this ingredient profile.
Interactions
Information not yet available for this ingredient profile.
Evidence and Scientific Findings
Ingredient Overview
Safed Musli (Chlorophytum borivilianum) root is an Ayurvedic adaptogen used for male vitality, libido, and as a general tonic. It is rich in saponins and polysaccharides. Human clinical safety data is limited to small trials. It is generally well tolerated at standard doses with mild GI effects (loose stools) reported at higher doses. No significant drug interactions are documented. Avoid during pregnancy and lactation due to lack of safety data.
Biological and Chemical Classification
- Scientific Name
- Chlorophytum borivilianum
Mechanism of Action
Information not yet available for this ingredient profile.
Clinical Evidence of Effectiveness
Information not yet available for this ingredient profile.
Pharmacokinetics
Information not yet available for this ingredient profile.
Recommended Dosage
Information not yet available for this ingredient profile.
SETI — Scientific Evidence Transparency Index
Executive Summary — Ingredient Assessment
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or RCT)
- Main clinical benefit observed: Botanical
- Evidence consistency: High consistency across studies (100%)
- No significant safety signals identified in the reviewed literature.
The available scientific evidence for Safed Musli indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.
Total SETI Score
High risk| Evidence quality | 10/40 |
| Evidence consistency | 20/20 |
| Safety signals | 0/20 |
| Study recency | 10/10 |
| Evidence transparency | 10/10 |
Evidence Summary
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or systematic review)
- 0 studies identified benefits or no safety concern (GREEN)
- 10 studies reported limited or advisory safety evidence (YELLOW)
Evidence Policy
Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.
Last updated: 06 აპრ 2026, 12:10
Evidence Distribution
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Observational / other LOW evidence YELLOWProfiling of saponins in four different species of Chlorophytum by liquid chromatography quadrupole time of flight mass spectrometry. ↗Khedkar SM et al.. Profiling of saponins in four different species of Chlorophytum by liquid chromatography quadrupole time of flight mass spectrometry.. Nat Prod Res. 2025. PMID:40720288.PMID 40720288 ↗Journal Nat Prod ResYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40720288/
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Observational / other LOW evidence YELLOWIn silico analysis of Chlorophytum borivilianum phytocompounds as a multi-targeted directed ligand (MTDL) against type 2 diabetes mellitus-induced Alzheimer's disease. ↗Khoba K et al.. In silico analysis of Chlorophytum borivilianum phytocompounds as a multi-targeted directed ligand (MTDL) against type 2 diabetes mellitus-induced Alzheimer's disease.. Nat Prod Res. 2025. PMID:40376790.PMID 40376790 ↗Journal Nat Prod ResYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40376790/
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Observational / other LOW evidence YELLOWIn silico discovery of potential novel anti-tuberculosis drug candidates from phytoconstituents of Chlorophytum borivilianum and Asparagus racemosus. ↗Ibrahim M et al.. In silico discovery of potential novel anti-tuberculosis drug candidates from phytoconstituents of Chlorophytum borivilianum and Asparagus racemosus.. Heliyon. 2025. PMID:40084025.PMID 40084025 ↗Journal HeliyonYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40084025/
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Observational / other LOW evidence YELLOWRole of Chlorophytum Borivilianum extract against Doxorubicin- induced Myocardial Toxicity in Albino Rats: Insilico and Invivo studies. ↗Nimbal SK et al.. Role of Chlorophytum Borivilianum extract against Doxorubicin- induced Myocardial Toxicity in Albino Rats: Insilico and Invivo studies.. Arch Razi Inst. 2024. PMID:40256579.PMID 40256579 ↗Journal Arch Razi InstYear 2024Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40256579/
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Observational / other LOW evidence YELLOWChlorophytum borivilianum aqueous root extract prevents deterioration of testicular function in mice and preserves human sperm function in hydrogen peroxide (H(2)O(2))-induced oxidative… ↗Mararajah S et al.. Chlorophytum borivilianum aqueous root extract prevents deterioration of testicular function in mice and preserves human sperm function in hydrogen peroxide (H(2)O(2))-induced oxidative stress.. J Ethnopharmacol. 2024. PMID:37572930.PMID 37572930 ↗Journal J EthnopharmacolYear 2024Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/37572930/
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Observational / other LOW evidence YELLOWExploring the therapeutic potential and bio-evaluation of muesli (Chlorophytum borivilianum) for the management of postprandial glucose management in healthy and diabetic female… ↗Amanat T et al.. Exploring the therapeutic potential and bio-evaluation of muesli (Chlorophytum borivilianum) for the management of postprandial glucose management in healthy and diabetic female subjects.. Pak J Pharm Sci. 2023. PMID:37548202.PMID 37548202 ↗Journal Pak J Pharm SciYear 2023Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/37548202/
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Observational / other LOW evidence YELLOWRadical scavenging activity of Chlorophytum borivilianum L. root extract and its protective role in cauda epididymal sperm integrity in Mus musculus after… ↗Vyas R et al.. Radical scavenging activity of Chlorophytum borivilianum L. root extract and its protective role in cauda epididymal sperm integrity in Mus musculus after gamma irradiation.. Front Cell Dev Biol. 2023. PMID:37025174.PMID 37025174 ↗Journal Front Cell Dev BiolYear 2023Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/37025174/
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Observational / other LOW evidence YELLOWHeterologous expression of Chlorophytum borivilianum Squalene epoxidase in tobacco modulates stigmasterol production and alters vegetative and reproductive growth. ↗Kaushal N et al.. Heterologous expression of Chlorophytum borivilianum Squalene epoxidase in tobacco modulates stigmasterol production and alters vegetative and reproductive growth.. Plant Cell Rep. 2023. PMID:36894686.PMID 36894686 ↗Journal Plant Cell RepYear 2023Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/36894686/
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Observational / other LOW evidence YELLOWMulti-mycotoxin analysis method using liquid chromatography with tandem mass spectrometry and fluorescence detection in Indian medicinal herbs: Development and validation. ↗Sarkar R et al.. Multi-mycotoxin analysis method using liquid chromatography with tandem mass spectrometry and fluorescence detection in Indian medicinal herbs: Development and validation.. J Chromatogr A. 2022. PMID:35853424.PMID 35853424 ↗Journal J Chromatogr AYear 2022Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/35853424/
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Observational / other LOW evidence YELLOWDifferential Activity of Antioxidants in Testicular Tissues Following Administration of Chlorophytum borivilianum in Gamma-Irradiated Swiss Albino Mice. ↗Vyas R et al.. Differential Activity of Antioxidants in Testicular Tissues Following Administration of Chlorophytum borivilianum in Gamma-Irradiated Swiss Albino Mice.. Front Pharmacol. 2021. PMID:35111049.PMID 35111049 ↗Journal Front PharmacolYear 2021Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/35111049/
Score Transparency
0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.
Method: Q = number of approved references ÷ 10 (capped at 1.0)
Limited — mostly case reports or animal studies
Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.
Mixed or neutral — roughly equal benefit and risk signals
Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.
One or more monitoring-level safety signals active
Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.
Final GIRI Score for Safed Musli. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
Full methodology & data sources
The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.
- References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
- Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
- Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
- Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
Risk Level Classification
Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.
0–3.0
3.0–5.5
5.5–7.5
7.5–10
The score pin shows exactly where this ingredient falls on the fixed risk scale.
What drove the Low classification for Safed Musli
A score of 2.0 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
0 approved references.
Limited — mostly case reports or animal studies (Level 4–5).
Neutral or mixed — benefit and risk signals roughly balanced.
No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.
No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).
How are the Low / Moderate / High / Critical thresholds defined?
The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:
| Level | Score | Meaning |
|---|---|---|
| LOW | 0.0 – 2.9 | Sparse or predominantly beneficial evidence. No active safety alerts. |
| MODERATE | 3.0 – 5.4 | Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups. |
| HIGH | 5.5 – 7.4 | Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended. |
| CRITICAL | 7.5 – 10 | Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision. |
Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.