Safety Profile
Information not yet available for this ingredient profile.
Interactions
Information not yet available for this ingredient profile.
Evidence and Scientific Findings
Ingredient Overview
Rosemary leaf extract is used as a natural antioxidant and for cognitive and circulatory support. It is safe at standard doses. It may mildly reduce iron absorption and interact with anticoagulants at very high doses. It has uterotonic properties; avoid high-dose supplementation in pregnancy. Safe in culinary amounts.
Biological and Chemical Classification
- Scientific Name
- Rosmarinus officinalis
Mechanism of Action
Information not yet available for this ingredient profile.
Clinical Evidence of Effectiveness
Information not yet available for this ingredient profile.
Pharmacokinetics
Information not yet available for this ingredient profile.
Recommended Dosage
Information not yet available for this ingredient profile.
SETI — Scientific Evidence Transparency Index
Executive Summary — Ingredient Assessment
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or RCT)
- Main clinical benefit observed: Botanical
- Evidence consistency: High consistency across studies (100%)
- No significant safety signals identified in the reviewed literature.
The available scientific evidence for Rosemary Leaf Extract indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.
Total SETI Score
High risk| Evidence quality | 10/40 |
| Evidence consistency | 20/20 |
| Safety signals | 0/20 |
| Study recency | 10/10 |
| Evidence transparency | 10/10 |
Evidence Summary
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or systematic review)
- 0 studies identified benefits or no safety concern (GREEN)
- 10 studies reported limited or advisory safety evidence (YELLOW)
Evidence Policy
Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.
Last updated: 06 ივნ 2026, 12:04
Evidence Distribution
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Observational / other LOW evidence YELLOWRosmanol alleviates glycerol-induced acute kidney injury through its antioxidative and anti-apoptotic properties via ameliorating the PGCu20111u03b1/SIRT3 signalling pathway. ↗Cheng H et al.. Rosmanol alleviates glycerol-induced acute kidney injury through its antioxidative and anti-apoptotic properties via ameliorating the PGCu20111u03b1/SIRT3 signalling pathway.. J Mol Histol. 2026. PMID:42249228.PMID 42249228 ↗Journal J Mol HistolYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/42249228/
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Observational / other LOW evidence YELLOWPotentials and challenges of an integrative medicine protocol in intensive care: the perspective of intensive care nurses. ↗Berlowitz I et al.. Potentials and challenges of an integrative medicine protocol in intensive care: the perspective of intensive care nurses.. BMC Complement Med Ther. 2026. PMID:42237325.PMID 42237325 ↗Journal BMC Complement Med TherYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/42237325/
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Observational / other LOW evidence YELLOWComputational evaluation of carnosic acid as a 4EY7 inhibitor for potential anti-Alzheimer therapy. ↗Alhamyani A. Computational evaluation of carnosic acid as a 4EY7 inhibitor for potential anti-Alzheimer therapy.. Front Aging Neurosci. 2026. PMID:42221029.PMID 42221029 ↗Journal Front Aging NeurosciYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/42221029/
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Observational / other LOW evidence YELLOWExtension of Sous Vide Preservation of Wild Turkey (Meleagris gallopavo L.) Meat With Rosmarinus officinalis Essential Oil: A Study on Chemical Composition… ↗Kau010du00e1niovu00e1 M et al.. Extension of Sous Vide Preservation of Wild Turkey (Meleagris gallopavo L.) Meat With Rosmarinus officinalis Essential Oil: A Study on Chemical Composition and Antibacterial Effectiveness Against Listeria monocytogenes and Other Population of Isolated Microbiota.. Environ Microbiol Rep. 2026. PMID:42212705.PMID 42212705 ↗Journal Environ Microbiol RepYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/42212705/
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Observational / other LOW evidence YELLOWComparative Evaluation of Pesticidal Potential of Five Aromatic Plants, with Emphasis on the Fungicidal Activity of Lavandula dentata and Thymus vulgaris Extracts… ↗Gropali A et al.. Comparative Evaluation of Pesticidal Potential of Five Aromatic Plants, with Emphasis on the Fungicidal Activity of Lavandula dentata and Thymus vulgaris Extracts Against the Soil-Borne Tomato Pathogens Fusarium oxysporum f.sp. radicis-lycopersici and Verticillium dahliae.. Microorganisms. 2026. PMID:42197387.PMID 42197387 ↗Journal MicroorganismsYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/42197387/
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Observational / other LOW evidence YELLOWTemperature stress-induced production of salicylic acid from endophytic Aspergillus flavus with its in silico and in vitro anti-inflammatory potential and promising effect… ↗Saleem A et al.. Temperature stress-induced production of salicylic acid from endophytic Aspergillus flavus with its in silico and in vitro anti-inflammatory potential and promising effect in combination with ibuprofen.. Front Microbiol. 2026. PMID:42137802.PMID 42137802 ↗Journal Front MicrobiolYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/42137802/
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Observational / other LOW evidence YELLOWDiet-Dependent Chemical Profiling and Bioactivity of Otala tingitana Mucus: Antibacterial Activity, Antioxidant Capacity, and In Vivo Wound-Healing Effects. ↗Khayari AE et al.. Diet-Dependent Chemical Profiling and Bioactivity of Otala tingitana Mucus: Antibacterial Activity, Antioxidant Capacity, and In Vivo Wound-Healing Effects.. Molecules. 2026. PMID:42123863.PMID 42123863 ↗Journal MoleculesYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/42123863/
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Observational / other LOW evidence YELLOWAn Exploratory Preclinical In Vivo Pilot Study Evaluating the Hair Growth-Promoting Effects of Rosmarinus officinalis and Ricinus communis Combination. ↗Mathenge A et al.. An Exploratory Preclinical In Vivo Pilot Study Evaluating the Hair Growth-Promoting Effects of Rosmarinus officinalis and Ricinus communis Combination.. Biomed Res Int. 2026. PMID:42112722.PMID 42112722 ↗Journal Biomed Res IntYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/42112722/
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Observational / other LOW evidence YELLOWSelenium-Bearing Conducting Polymer/Graphene Quantum Dot Hybrid for Enzyme Based Electrochemical Biosensor Targeting Tyrosinase Inhibition Via Rosmarinic Acid. ↗Alhardan R et al.. Selenium-Bearing Conducting Polymer/Graphene Quantum Dot Hybrid for Enzyme Based Electrochemical Biosensor Targeting Tyrosinase Inhibition Via Rosmarinic Acid.. ChemistryOpen. 2026. PMID:42108709.PMID 42108709 ↗Journal ChemistryOpenYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/42108709/
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Observational / other LOW evidence YELLOWA stabilized enrichment method for rosemary diterpenoids and their therapeutic potential in diabetic kidney disease. ↗Wei J et al.. A stabilized enrichment method for rosemary diterpenoids and their therapeutic potential in diabetic kidney disease.. Chin Med. 2026. PMID:42092960.PMID 42092960 ↗Journal Chin MedYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/42092960/
Score Transparency
0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.
Method: Q = number of approved references ÷ 10 (capped at 1.0)
Limited — mostly case reports or animal studies
Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.
Mixed or neutral — roughly equal benefit and risk signals
Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.
One or more monitoring-level safety signals active
Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.
Final GIRI Score for Rosemary Leaf Extract. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
Full methodology & data sources
The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.
- References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
- Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
- Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
- Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
Risk Level Classification
Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.
0–3.0
3.0–5.5
5.5–7.5
7.5–10
The score pin shows exactly where this ingredient falls on the fixed risk scale.
What drove the Low classification for Rosemary Leaf Extract
A score of 1.5 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
0 approved references.
Limited — mostly case reports or animal studies (Level 4–5).
Neutral or mixed — benefit and risk signals roughly balanced.
No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.
No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).
How are the Low / Moderate / High / Critical thresholds defined?
The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:
| Level | Score | Meaning |
|---|---|---|
| LOW | 0.0 – 2.9 | Sparse or predominantly beneficial evidence. No active safety alerts. |
| MODERATE | 3.0 – 5.4 | Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups. |
| HIGH | 5.5 – 7.4 | Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended. |
| CRITICAL | 7.5 – 10 | Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision. |
Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.