Global Ingredient Risk Index Botanical

Rosemary Extract

Rosmarinus officinalis leaf extract (E392)

Also known as: rosemary extract, rosemary antioxidant, E392, rosmarinic acid extract

25 მარ 2026

LOW RISK 2.5/10 How?

This ingredient is classified as unclassified risk (GIRI score: 2.5/10).

Known Safety Concerns

At therapeutic doses: anticoagulant and ACE inhibitor interactions
At preservative amounts: essentially no risk
Rare contact dermatitis and cross-reactivity with other Lamiaceae plants
Pregnancy: therapeutic doses may stimulate uterus (preservative amounts are safe)

Contraindications

At therapeutic doses: anticoagulant and ACE inhibitor interactions
At preservative amounts: essentially no risk

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Information not yet available for this ingredient profile.

Rosemary extract is used as a natural antioxidant preservative in oil-based supplements. It contains rosmarinic acid and carnosic acid. At the small amounts used as a preservative it is extremely safe. At higher therapeutic doses it may interact with anticoagulants, ACE inhibitors, and diuretics.

Scientific Name: Rosmarinus officinalis leaf extract (E392)

Information not yet available for this ingredient profile.

SETI Score 50/100

Risk Level High risk

Scientific Confidence Low

Evidence Strength Limited

Key Benefit Botanical

Key Safety Concern At therapeutic doses: anticoagulant and ACE inhibitor interactions

Evidence Reviewed 10 PubMed studies

Scientific Confidence Low

Based on study quality, consistency, and recency

Executive Summary — Ingredient Assessment

SETI Score 50/100

Risk Level High risk

Evidence Strength Limited

Main Benefit Botanical

Main Safety Concern At therapeutic doses: anticoagulant and ACE inhibitor interactions

Ingredient Rosemary Extract

Scientific name Rosmarinus officinalis leaf extract (E392)

Scientific Evidence Overview

10 studies reviewed
0 high-quality studies (meta-analysis or RCT)
Main clinical benefit observed: Botanical
Evidence consistency: High consistency across studies (100%)

Safety Signals

At therapeutic doses: anticoagulant and ACE inhibitor interactions
At preservative amounts: essentially no risk
Rare contact dermatitis and cross-reactivity with other Lamiaceae plants
Pregnancy: therapeutic doses may stimulate uterus (preservative amounts are safe)

Evidence Strength Limited

Final Scientific Assessment

The available scientific evidence for Rosemary Extract indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.

Ingredient Rosemary Extract

Evidence reviewed 10 peer-reviewed studies (last 10 years)

Scientific name Rosmarinus officinalis leaf extract (E392)

50 /100

Total SETI Score

High risk

Evidence quality	10/40
Evidence consistency	20/20
Safety signals	0/20
Study recency	10/10
Evidence transparency	10/10

Evidence Summary

10 studies reviewed
0 high-quality studies (meta-analysis or systematic review)
0 studies identified benefits or no safety concern (GREEN)
10 studies reported limited or advisory safety evidence (YELLOW)

Evidence Policy

Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.

Last updated: 25 მარ 2026, 13:03

Evidence Distribution

10 Other / unclassified

Observational / other LOW evidence YELLOW
Effectiveness of rosemary extract on the cardiovascular risk of emergency nursing professionals - an intervention study. ↗

PMID 41861393 ↗

Journal Rev Esc Enferm USP

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41861393/

Pretto CR et al.. Effectiveness of rosemary extract on the cardiovascular risk of emergency nursing professionals - an intervention study.. Rev Esc Enferm USP. 2026. PMID:41861393.
Observational / other LOW evidence YELLOW
Maternal antioxidant supplementation enhances oxidative balance, milk bioactivity, and neonatal performance in Beetal goats during the transition period. ↗

PMID 41822568 ↗

Journal Vet World

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41822568/

Zaib G et al.. Maternal antioxidant supplementation enhances oxidative balance, milk bioactivity, and neonatal performance in Beetal goats during the transition period.. Vet World. 2026. PMID:41822568.
Observational / other LOW evidence YELLOW
Oxidation Strength of PLA Filled with Algal Biomass and Rosemary Extract Powders for Food-Safe Handling. ↗

PMID 41754693 ↗

Journal Polymers (Basel)

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41754693/

Zaharescu T et al.. Oxidation Strength of PLA Filled with Algal Biomass and Rosemary Extract Powders for Food-Safe Handling.. Polymers (Basel). 2026. PMID:41754693.
Observational / other LOW evidence YELLOW
Tannin Rich-Extracts: Natural Solutions for Preserving the Physicochemical, Oxidative, and Microbiological Quality of Beef Patties During Cold Storage. ↗

PMID 41750577 ↗

Journal Antioxidants (Basel)

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41750577/

Potenziani G et al.. Tannin Rich-Extracts: Natural Solutions for Preserving the Physicochemical, Oxidative, and Microbiological Quality of Beef Patties During Cold Storage.. Antioxidants (Basel). 2026. PMID:41750577.
Observational / other LOW evidence YELLOW
Green fabrication of CuO-Fe(2)O(3) and CuO-Fe(2)O(3)@Chitin nanocomposites using rosemary extract: Structural, antioxidant, antibacterial, and catalytic Indigo Carmine dye degradation performance. ↗

PMID 41724300 ↗

Journal Int J Biol Macromol

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41724300/

Alanazi AA et al.. Green fabrication of CuO-Fe(2)O(3) and CuO-Fe(2)O(3)@Chitin nanocomposites using rosemary extract: Structural, antioxidant, antibacterial, and catalytic Indigo Carmine dye degradation performance.. Int J Biol Macromol. 2026. PMID:41724300.
Observational / other LOW evidence YELLOW
Biological functions and applications of rosemary extracts in animal production. ↗

PMID 41716831 ↗

Journal Anim Nutr

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41716831/

Liu Z et al.. Biological functions and applications of rosemary extracts in animal production.. Anim Nutr. 2026. PMID:41716831.
Observational / other LOW evidence YELLOW
Effects of Nanoemulsions' Droplet Size and Natural Antioxidants' Hydrophilicity on Oxidative Stability and Mechanical Properties of Alginate Beads Filled with Linseed Oil… ↗

PMID 41683102 ↗

Journal Foods

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41683102/

Rahiminezhad Z et al.. Effects of Nanoemulsions' Droplet Size and Natural Antioxidants' Hydrophilicity on Oxidative Stability and Mechanical Properties of Alginate Beads Filled with Linseed Oil Nanoemulsion.. Foods. 2026. PMID:41683102.
Observational / other LOW evidence YELLOW
Biobased chitosan films incorporating rosemary-mediated silver nanoparticles for enhanced antimicrobial activity and catalytic applications. ↗

PMID 41672173 ↗

Journal Int J Biol Macromol

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41672173/

El Fedyl L et al.. Biobased chitosan films incorporating rosemary-mediated silver nanoparticles for enhanced antimicrobial activity and catalytic applications.. Int J Biol Macromol. 2026. PMID:41672173.
Observational / other LOW evidence YELLOW
Production of unsaturated fatty acids in an internal-ripened cheese. ↗

PMID 41652711 ↗

Journal Food Res Int

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41652711/

Shi H et al.. Production of unsaturated fatty acids in an internal-ripened cheese.. Food Res Int. 2026. PMID:41652711.
Observational / other LOW evidence YELLOW
Review on natural remedies for hair growth promotion with a focus on rosemary. ↗

PMID 41630600 ↗

Journal Dermatol Reports

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41630600/

Almutairi AG et al.. Review on natural remedies for hair growth promotion with a focus on rosemary.. Dermatol Reports. 2026. PMID:41630600.

Q × L × D × S × 10 = 2.5 / 10

The GIRI Score is the product of four independently computed evidence components, each normalised to 0–1, then scaled to 0–10. Every component is derived exclusively from peer-reviewed references and regulatory data — no editorial judgement is applied.

0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.

Method: Q = number of approved references ÷ 10 (capped at 1.0)

50%

Limited — mostly case reports or animal studies

Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.

Benefit

Risk

50%

Mixed or neutral — roughly equal benefit and risk signals

Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.

50%

One or more monitoring-level safety signals active

Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.

0Q × 5L × 5D × 5S = 2.5 / 10

Final GIRI Score for Rosemary Extract. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

Full methodology & data sources

The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.

References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.

LOW RISK 2.5/10

Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.

LOW
0–3.0

MODERATE
3.0–5.5

HIGH
5.5–7.5

CRITICAL
7.5–10

2.5

The score pin shows exactly where this ingredient falls on the fixed risk scale.

What drove the Low classification for Rosemary Extract

A score of 2.5 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

0 approved references.

Limited — mostly case reports or animal studies (Level 4–5).

Neutral or mixed — benefit and risk signals roughly balanced.

No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.

No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).

How are the Low / Moderate / High / Critical thresholds defined?

The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:

Level	Score	Meaning
LOW	0.0 – 2.9	Sparse or predominantly beneficial evidence. No active safety alerts.
MODERATE	3.0 – 5.4	Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups.
HIGH	5.5 – 7.4	Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended.
CRITICAL	7.5 – 10	Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision.

Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.

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Rosemary Extract

Safety Profile

Known Safety Concerns

Contraindications

Interactions

Evidence and Scientific Findings

Ingredient Overview

Biological and Chemical Classification

Mechanism of Action

Clinical Evidence of Effectiveness

Pharmacokinetics

Recommended Dosage

SETI — Scientific Evidence Transparency Index

Executive Summary — Ingredient Assessment

Evidence Summary

Evidence Policy

Evidence Distribution

Score Transparency

Risk Level Classification

What drove the Low classification for Rosemary Extract

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