Safety Profile
Known Safety Concerns
- Seed hairs cause GI irritation -- ensure properly processed seed-free extract
- Vitamin C content adds to total ascorbic acid intake
- Mild diuretic effect at high doses
- Very well tolerated -- one of the safest botanical supplements
Contraindications
- Seed hairs cause GI irritation -- ensure properly processed seed-free extract
- Vitamin C content adds to total ascorbic acid intake
Interactions
Information not yet available for this ingredient profile.
Evidence and Scientific Findings
Ingredient Overview
Rose hips are the fruit of Rosa canina and related species, used as a vitamin C source and antioxidant. They contain vitamin C, carotenoids, polyphenols, and anti-inflammatory glycoside GOPO. Clinical evidence for osteoarthritis pain is moderately positive. Very well tolerated. The seeds inside must be removed — seed hairs cause GI irritation.
Biological and Chemical Classification
- Scientific Name
- Rosa canina fruit extract
Mechanism of Action
Information not yet available for this ingredient profile.
Clinical Evidence of Effectiveness
Information not yet available for this ingredient profile.
Pharmacokinetics
Information not yet available for this ingredient profile.
Recommended Dosage
Information not yet available for this ingredient profile.
SETI — Scientific Evidence Transparency Index
Executive Summary — Ingredient Assessment
- 7 studies reviewed
- 0 high-quality studies (meta-analysis or RCT)
- Main clinical benefit observed: Botanical
- Evidence consistency: High consistency across studies (100%)
- Seed hairs cause GI irritation -- ensure properly processed seed-free extract
- Vitamin C content adds to total ascorbic acid intake
- Mild diuretic effect at high doses
- Very well tolerated -- one of the safest botanical supplements
The available scientific evidence for Rose Hips Extract indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.
Total SETI Score
High risk| Evidence quality | 7/40 |
| Evidence consistency | 20/20 |
| Safety signals | 6/20 |
| Study recency | 10/10 |
| Evidence transparency | 10/10 |
Evidence Summary
- 7 studies reviewed
- 0 high-quality studies (meta-analysis or systematic review)
- 0 studies identified benefits or no safety concern (GREEN)
- 7 studies reported limited or advisory safety evidence (YELLOW)
Evidence Policy
Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.
Last updated: 25 მარ 2026, 12:53
Evidence Distribution
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Observational / other LOW evidence YELLOWProtective effects of Rosa canina fruit extract against kidney damage induced by CCl4. ↗Gazwi HSS et al.. Protective effects of Rosa canina fruit extract against kidney damage induced by CCl4.. Regul Toxicol Pharmacol. 2025. PMID:40685065.PMID 40685065 ↗Journal Regul Toxicol PharmacolYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40685065/
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Observational / other LOW evidence YELLOWDesign and Characterization of Liposomal-Based Carriers for the Encapsulation of Rosa canina Fruit Extract: In Vitro Gastrointestinal Release Behavior. ↗Jovanoviu0107 AA et al.. Design and Characterization of Liposomal-Based Carriers for the Encapsulation of Rosa canina Fruit Extract: In Vitro Gastrointestinal Release Behavior.. Plants (Basel). 2024. PMID:39339584.PMID 39339584 ↗Journal Plants (Basel)Year 2024Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/39339584/
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Observational / other LOW evidence YELLOWAssessment of Bioactive Phytochemicals and Utilization of Rosa canina Fruit Extract as a Novel Natural Antioxidant for Mayonnaise. ↗Soltan OIA et al.. Assessment of Bioactive Phytochemicals and Utilization of Rosa canina Fruit Extract as a Novel Natural Antioxidant for Mayonnaise.. Molecules. 2023. PMID:37110582.PMID 37110582 ↗Journal MoleculesYear 2023Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/37110582/
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Observational / other LOW evidence YELLOWEffect of the green synthesized rGO and Mg/rGO nanocomposites on the phytochemical assay, toxicity, and metabolism of Mentha longifolia in vitro cultures. ↗Jafarirad S et al.. Effect of the green synthesized rGO and Mg/rGO nanocomposites on the phytochemical assay, toxicity, and metabolism of Mentha longifolia in vitro cultures.. Environ Sci Pollut Res Int. 2022. PMID:35167020.PMID 35167020 ↗Journal Environ Sci Pollut Res IntYear 2022Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/35167020/
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Observational / other LOW evidence YELLOWGreen synthesis of Pd nanoparticles supported on reduced graphene oxide, using the extract of Rosa canina fruit, and their use as recyclable… ↗Hemmati S et al.. Green synthesis of Pd nanoparticles supported on reduced graphene oxide, using the extract of Rosa canina fruit, and their use as recyclable and heterogeneous nanocatalysts for the degradation of dye pollutants in water.. RSC Adv. 2018. PMID:35542342.PMID 35542342 ↗Journal RSC AdvYear 2018Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/35542342/
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Observational / other LOW evidence YELLOWHepatoprotective effect of Rosa canina fruit extract against carbon tetrachloride induced hepatotoxicity in rat. ↗Sadeghi H et al.. Hepatoprotective effect of Rosa canina fruit extract against carbon tetrachloride induced hepatotoxicity in rat.. Avicenna J Phytomed. 2016. PMID:27222831.PMID 27222831 ↗Journal Avicenna J PhytomedYear 2016Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/27222831/
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Observational / other LOW evidence YELLOWAntidiabetic and Antihyperlipidemic Effects of Ethanol Extract of Rosa canina L. fruit on Diabetic Rats: An Experimental Study With Histopathological Evaluations. ↗Taghizadeh M et al.. Antidiabetic and Antihyperlipidemic Effects of Ethanol Extract of Rosa canina L. fruit on Diabetic Rats: An Experimental Study With Histopathological Evaluations.. J Evid Based Complementary Altern Med. 2016. PMID:26498488.PMID 26498488 ↗Journal J Evid Based Complementary Altern MedYear 2016Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/26498488/
Score Transparency
0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.
Method: Q = number of approved references ÷ 10 (capped at 1.0)
Limited — mostly case reports or animal studies
Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.
Mixed or neutral — roughly equal benefit and risk signals
Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.
One or more monitoring-level safety signals active
Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.
Final GIRI Score for Rose Hips Extract. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
Full methodology & data sources
The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.
- References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
- Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
- Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
- Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
Risk Level Classification
Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.
0–3.0
3.0–5.5
5.5–7.5
7.5–10
The score pin shows exactly where this ingredient falls on the fixed risk scale.
What drove the Low classification for Rose Hips Extract
A score of 2.0 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
0 approved references.
Limited — mostly case reports or animal studies (Level 4–5).
Neutral or mixed — benefit and risk signals roughly balanced.
No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.
No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).
How are the Low / Moderate / High / Critical thresholds defined?
The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:
| Level | Score | Meaning |
|---|---|---|
| LOW | 0.0 – 2.9 | Sparse or predominantly beneficial evidence. No active safety alerts. |
| MODERATE | 3.0 – 5.4 | Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups. |
| HIGH | 5.5 – 7.4 | Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended. |
| CRITICAL | 7.5 – 10 | Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision. |
Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.