ორშაბათი, აპრილი 13, 2026
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Global Ingredient Risk Index Botanical

Red Raspberry Fruit Extract

Rubus idaeus

Also known as: Raspberry ketone, Rubus idaeus extract, Raspberry extract

LOW RISK 1.5/10 How?

This ingredient is classified as unclassified risk (GIRI score: 1.5/10).

02

Safety Profile

Information not yet available for this ingredient profile.

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03

Interactions

Information not yet available for this ingredient profile.

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04

Evidence and Scientific Findings

Overview

Ingredient Overview

Red raspberry fruit extract is used for antioxidant effects and in weight loss products as raspberry ketones. The berry extract is very safe. Raspberry ketone supplements lack clinical safety data at supplemental doses and may have stimulant effects. The berry extract itself has an excellent safety record with no significant drug interactions.

Classification

Biological and Chemical Classification

Scientific Name
Rubus idaeus
Mechanism

Mechanism of Action

Information not yet available for this ingredient profile.

Clinical Evidence

Clinical Evidence of Effectiveness

Information not yet available for this ingredient profile.

Pharmacokinetics

Pharmacokinetics

Information not yet available for this ingredient profile.

Dosage

Recommended Dosage

Information not yet available for this ingredient profile.

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05

SETI — Scientific Evidence Transparency Index

SETI Score 50/100
Risk Level High risk
Scientific Confidence Low
Evidence Strength Limited
Key Benefit Botanical
Evidence Reviewed 10 PubMed studies
Scientific Confidence Low
Based on study quality, consistency, and recency

Executive Summary — Ingredient Assessment

SETI Score 50/100
Risk Level High risk
Evidence Strength Limited
Main Benefit Botanical
Ingredient Red Raspberry Fruit Extract
Scientific name Rubus idaeus
Scientific Evidence Overview
  • 10 studies reviewed
  • 0 high-quality studies (meta-analysis or RCT)
  • Main clinical benefit observed: Botanical
  • Evidence consistency: High consistency across studies (100%)
Safety Signals
  • No significant safety signals identified in the reviewed literature.
Evidence Strength Limited
Final Scientific Assessment

The available scientific evidence for Red Raspberry Fruit Extract indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.

Ingredient Red Raspberry Fruit Extract
Evidence reviewed 10 peer-reviewed studies (last 10 years)
Scientific name Rubus idaeus
50 /100

Total SETI Score

High risk
Evidence quality 10/40
Evidence consistency 20/20
Safety signals 0/20
Study recency 10/10
Evidence transparency 10/10

Evidence Summary

  • 10 studies reviewed
  • 0 high-quality studies (meta-analysis or systematic review)
  • 0 studies identified benefits or no safety concern (GREEN)
  • 10 studies reported limited or advisory safety evidence (YELLOW)

Evidence Policy

Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.

Last updated: 26 მარ 2026, 14:37

Evidence Distribution

10 Other / unclassified
  1. Observational / other LOW evidence YELLOW
    The origin of the octoploid cloudberry (Rubus chamaemorus) genome is the result of multiple and complex polyploidization events. ↗
    PMID 41879285 ↗
    Journal J Hered
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41879285/
    Strand MA et al.. The origin of the octoploid cloudberry (Rubus chamaemorus) genome is the result of multiple and complex polyploidization events.. J Hered. 2026. PMID:41879285.
  2. Observational / other LOW evidence YELLOW
    Development of a Flex-Seq SNP panel for raspberry (Rubus idaeus L.) and validation through linkage map construction and identification of QTL for… ↗
    PMID 41701706 ↗
    Journal PLoS One
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41701706/
    Davik J et al.. Development of a Flex-Seq SNP panel for raspberry (Rubus idaeus L.) and validation through linkage map construction and identification of QTL for several traits of agronomic importance to raspberry breeding.. PLoS One. 2026. PMID:41701706.
  3. Observational / other LOW evidence YELLOW
    Active Polysaccharide Films Incorporating Cannabis sativa Flower Extract for Extending the Shelf Life of Freeze-Dried Berries. ↗
    PMID 41683420 ↗
    Journal Molecules
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41683420/
    Dobrucka R et al.. Active Polysaccharide Films Incorporating Cannabis sativa Flower Extract for Extending the Shelf Life of Freeze-Dried Berries.. Molecules. 2026. PMID:41683420.
  4. Observational / other LOW evidence YELLOW
    Beyond prescription medicine in pregnancy - raspberry leaf and other herbs in Australia. ↗
    PMID 41668030 ↗
    Journal BMC Complement Med Ther
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41668030/
    Bowman RL et al.. Beyond prescription medicine in pregnancy - raspberry leaf and other herbs in Australia.. BMC Complement Med Ther. 2026. PMID:41668030.
  5. Observational / other LOW evidence YELLOW
    Raspberry protective role in inflammatory diseases: An overview. ↗
    PMID 41641148 ↗
    Journal Iran J Basic Med Sci
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41641148/
    Arya P et al.. Raspberry protective role in inflammatory diseases: An overview.. Iran J Basic Med Sci. 2026. PMID:41641148.
  6. Observational / other LOW evidence YELLOW
    Red raspberry improves postprandial metabolic indices and cognitive function in older adults who are overweight or have obesity. ↗
    PMID 41536265 ↗
    Journal Br J Nutr
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41536265/
    Xiao D et al.. Red raspberry improves postprandial metabolic indices and cognitive function in older adults who are overweight or have obesity.. Br J Nutr. 2026. PMID:41536265.
  7. Observational / other LOW evidence YELLOW
    Ellagitannins from red raspberry (Rubus idaeus L.): a comprehensive review on chemistry characteristics and beneficial effects. ↗
    PMID 41527457 ↗
    Journal Food Funct
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41527457/
    Tao M et al.. Ellagitannins from red raspberry (Rubus idaeus L.): a comprehensive review on chemistry characteristics and beneficial effects.. Food Funct. 2026. PMID:41527457.
  8. Observational / other LOW evidence YELLOW
    Influence of u03b2-Cyclodextrin on the Overall Antioxidant Activity and DPPHu00b7 Reaction Kinetics of Fresh Raspberry (Rubus idaeus L.) and Dehydrated Strawberry (Fragaria… ↗
    PMID 41515097 ↗
    Journal Plants (Basel)
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41515097/
    Fiu0163oiu Voin M et al.. Influence of u03b2-Cyclodextrin on the Overall Antioxidant Activity and DPPHu00b7 Reaction Kinetics of Fresh Raspberry (Rubus idaeus L.) and Dehydrated Strawberry (Fragaria u00d7 ananassa Duch.) Extracts.. Plants (Basel). 2026. PMID:41515097.
  9. Observational / other LOW evidence YELLOW
    Bioproduction of raspberry ketone using Phyllostachys bamboo cells expressing raspberry ketone biosynthetic genes. ↗
    PMID 41523589 ↗
    Journal Plant Biotechnol (Tokyo)
    Year 2025
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41523589/
    Koeduka T et al.. Bioproduction of raspberry ketone using Phyllostachys bamboo cells expressing raspberry ketone biosynthetic genes.. Plant Biotechnol (Tokyo). 2025. PMID:41523589.
  10. Observational / other LOW evidence YELLOW
    Physicochemical Properties of Berry Seeds Recovered from Pomace and Their Potential Applications in Food and Cosmetic Industries. ↗
    PMID 41515920 ↗
    Journal Int J Mol Sci
    Year 2025
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41515920/
    Kieu0142tyka-Dadasiewicz A et al.. Physicochemical Properties of Berry Seeds Recovered from Pomace and Their Potential Applications in Food and Cosmetic Industries.. Int J Mol Sci. 2025. PMID:41515920.
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06

Score Transparency

Q × L × D × S × 10 = 1.5 / 10

The GIRI Score is the product of four independently computed evidence components, each normalised to 0–1, then scaled to 0–10. Every component is derived exclusively from peer-reviewed references and regulatory data — no editorial judgement is applied.

Q
Evidence Quantity 0 / 10
0%

0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.

Method: Q = number of approved references ÷ 10 (capped at 1.0)

L
Evidence Quality 5 / 10
50%

Limited — mostly case reports or animal studies

Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.

D
Evidence Direction 5 / 10
Benefit
Risk
50%

Mixed or neutral — roughly equal benefit and risk signals

Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.

S
Safety Signals 5 / 10
50%

One or more monitoring-level safety signals active

Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.

0Q × 5L × 5D × 5S = 1.5 / 10

Final GIRI Score for Red Raspberry Fruit Extract. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

Full methodology & data sources

The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.

  • References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
  • Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
  • Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
  • Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
07

Risk Level Classification

LOW RISK 1.5/10

Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.

LOW
0–3.0
MODERATE
3.0–5.5
HIGH
5.5–7.5
CRITICAL
7.5–10
1.5

The score pin shows exactly where this ingredient falls on the fixed risk scale.

What drove the Low classification for Red Raspberry Fruit Extract

GIRI Score 1.5 / 10

A score of 1.5 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

Evidence Quantity (Q) 0 / 10 refs

0 approved references.

Evidence Quality (L) 50%

Limited — mostly case reports or animal studies (Level 4–5).

Evidence Direction (D) 50% toward risk

Neutral or mixed — benefit and risk signals roughly balanced.

Safety Signals (S) 0 active signals

No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.

Regulatory Status No restrictions found

No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).

How are the Low / Moderate / High / Critical thresholds defined?

The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:

LevelScoreMeaning
LOW0.0 – 2.9Sparse or predominantly beneficial evidence. No active safety alerts.
MODERATE3.0 – 5.4Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups.
HIGH5.5 – 7.4Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended.
CRITICAL7.5 – 10Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision.

Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.

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