Safety Profile
Information not yet available for this ingredient profile.
Interactions
Information not yet available for this ingredient profile.
Evidence and Scientific Findings
Ingredient Overview
Phytase is a digestive enzyme that degrades phytic acid (phytate) in plant foods, improving absorption of iron, zinc, calcium, and magnesium. Very safe at supplemental doses. May meaningfully increase absorption of these minerals — relevant consideration for individuals taking iron supplements or with haemochromatosis.
Biological and Chemical Classification
Information not yet available for this ingredient profile.
Mechanism of Action
Information not yet available for this ingredient profile.
Clinical Evidence of Effectiveness
Information not yet available for this ingredient profile.
Pharmacokinetics
Information not yet available for this ingredient profile.
Recommended Dosage
Information not yet available for this ingredient profile.
SETI — Scientific Evidence Transparency Index
Executive Summary — Ingredient Assessment
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or RCT)
- Main clinical benefit observed: Enzymes
- Evidence consistency: High consistency across studies (100%)
- No significant safety signals identified in the reviewed literature.
The available scientific evidence for Phytase indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.
Total SETI Score
High risk| Evidence quality | 10/40 |
| Evidence consistency | 20/20 |
| Safety signals | 0/20 |
| Study recency | 10/10 |
| Evidence transparency | 10/10 |
Evidence Summary
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or systematic review)
- 0 studies identified benefits or no safety concern (GREEN)
- 10 studies reported limited or advisory safety evidence (YELLOW)
Evidence Policy
Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.
Last updated: 06 აპრ 2026, 12:11
Evidence Distribution
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Observational / other LOW evidence YELLOWPlant Phosphorus Acquisition and Phytochemical Enhancement: A Synergistic Effect of Phytate-Intercalated Zn-Fe Layered Double Hydroxide and Phytase-Producing Rhizobacteria. ↗Gogoi R et al.. Plant Phosphorus Acquisition and Phytochemical Enhancement: A Synergistic Effect of Phytate-Intercalated Zn-Fe Layered Double Hydroxide and Phytase-Producing Rhizobacteria.. J Agric Food Chem. 2026. PMID:41913705.PMID 41913705 ↗Journal J Agric Food ChemYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41913705/
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Observational / other LOW evidence YELLOWImproved thermostability and catalytic performance of bacterial phytase via chitosan hydrogel immobilization. ↗Mohammadzadeh Naneh Karan A et al.. Improved thermostability and catalytic performance of bacterial phytase via chitosan hydrogel immobilization.. Int J Biol Macromol. 2026. PMID:41905692.PMID 41905692 ↗Journal Int J Biol MacromolYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41905692/
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Observational / other LOW evidence YELLOWGenetic, age, and diet effects on phytate degradation of laying hens studied in combined in vivo and in vitro assays. ↗Hanauska A et al.. Genetic, age, and diet effects on phytate degradation of laying hens studied in combined in vivo and in vitro assays.. Front Physiol. 2026. PMID:41878733.PMID 41878733 ↗Journal Front PhysiolYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41878733/
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Observational / other LOW evidence YELLOW[A single-point mutation enhances phytase thermostability through remodeling distant salt bridges]. ↗Lin W et al.. [A single-point mutation enhances phytase thermostability through remodeling distant salt bridges].. Sheng Wu Gong Cheng Xue Bao. 2026. PMID:41873074.PMID 41873074 ↗Journal Sheng Wu Gong Cheng Xue BaoYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41873074/
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Observational / other LOW evidence YELLOWSupplementation of exogenous enzymes and a reducing agent in broilers fed red sorghum-wheat blended diets. ↗Kim E et al.. Supplementation of exogenous enzymes and a reducing agent in broilers fed red sorghum-wheat blended diets.. Poult Sci. 2026. PMID:41863977.PMID 41863977 ↗Journal Poult SciYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41863977/
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Observational / other LOW evidence YELLOWScreening of probiotics for promoting mineral absorption based on in vitro fermentation and cell models. ↗Liu B et al.. Screening of probiotics for promoting mineral absorption based on in vitro fermentation and cell models.. Front Microbiol. 2026. PMID:41834858.PMID 41834858 ↗Journal Front MicrobiolYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41834858/
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Observational / other LOW evidence YELLOWComparative evaluation of phytate and phytase addition on growth performance and nutrient utilization efficiency in broilers and ducks. ↗Pirzado SA et al.. Comparative evaluation of phytate and phytase addition on growth performance and nutrient utilization efficiency in broilers and ducks.. Poult Sci. 2026. PMID:41833114.PMID 41833114 ↗Journal Poult SciYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41833114/
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Observational / other LOW evidence YELLOWProduction of Gamma-Aminobutyric Acid by Levilactobacillus brevis AK19B: Strain Characterization and Process Optimization Using Box-Behnken Design. ↗Memiu015f H et al.. Production of Gamma-Aminobutyric Acid by Levilactobacillus brevis AK19B: Strain Characterization and Process Optimization Using Box-Behnken Design.. Probiotics Antimicrob Proteins. 2026. PMID:41817892.PMID 41817892 ↗Journal Probiotics Antimicrob ProteinsYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41817892/
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Observational / other LOW evidence YELLOWEffects of Superdose phytase and acidifier supplementation in a phosphorus-deficient diet on growth performance, carcass characteristics, Cecal microbiota, and intestinal and liver… ↗Farzanegan A et al.. Effects of Superdose phytase and acidifier supplementation in a phosphorus-deficient diet on growth performance, carcass characteristics, Cecal microbiota, and intestinal and liver morphology in broiler chickens.. Vet Anim Sci. 2026. PMID:41810121.PMID 41810121 ↗Journal Vet Anim SciYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41810121/
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Observational / other LOW evidence YELLOWThe essential role of methylation in maize (Zea mays) defense against the seed-colonizing fungus Aspergillus flavus. ↗Parakkunnel R et al.. The essential role of methylation in maize (Zea mays) defense against the seed-colonizing fungus Aspergillus flavus.. 3 Biotech. 2026. PMID:41808726.PMID 41808726 ↗Journal 3 BiotechYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41808726/
Score Transparency
0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.
Method: Q = number of approved references ÷ 10 (capped at 1.0)
Limited — mostly case reports or animal studies
Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.
Mixed or neutral — roughly equal benefit and risk signals
Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.
One or more monitoring-level safety signals active
Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.
Final GIRI Score for Phytase. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
Full methodology & data sources
The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.
- References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
- Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
- Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
- Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
Risk Level Classification
Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.
0–3.0
3.0–5.5
5.5–7.5
7.5–10
The score pin shows exactly where this ingredient falls on the fixed risk scale.
What drove the Low classification for Phytase
A score of 1.0 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
0 approved references.
Limited — mostly case reports or animal studies (Level 4–5).
Neutral or mixed — benefit and risk signals roughly balanced.
No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.
No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).
How are the Low / Moderate / High / Critical thresholds defined?
The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:
| Level | Score | Meaning |
|---|---|---|
| LOW | 0.0 – 2.9 | Sparse or predominantly beneficial evidence. No active safety alerts. |
| MODERATE | 3.0 – 5.4 | Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups. |
| HIGH | 5.5 – 7.4 | Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended. |
| CRITICAL | 7.5 – 10 | Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision. |
Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.