Safety Profile
Information not yet available for this ingredient profile.
Interactions
Information not yet available for this ingredient profile.
Evidence and Scientific Findings
Ingredient Overview
Chlorella is a freshwater green algae used as a nutritional supplement for detoxification, immune support, and as a source of chlorophyll, vitamins, and minerals. Generally well tolerated. May cause green-colored stools. It binds heavy metals and can reduce warfarin efficacy (high Vitamin K content); monitor INR in patients on anticoagulants. Contamination with heavy metals or microcystins is a quality concern; choose tested, certified products. Photosensitivity reactions are rarely reported.
Biological and Chemical Classification
- Scientific Name
- Chlorella vulgaris
Mechanism of Action
Information not yet available for this ingredient profile.
Clinical Evidence of Effectiveness
Information not yet available for this ingredient profile.
Pharmacokinetics
Information not yet available for this ingredient profile.
Recommended Dosage
Information not yet available for this ingredient profile.
SETI — Scientific Evidence Transparency Index
Executive Summary — Ingredient Assessment
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or RCT)
- Main clinical benefit observed: Specialty
- Evidence consistency: High consistency across studies (100%)
- No significant safety signals identified in the reviewed literature.
The available scientific evidence for Organic Chlorella indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.
Total SETI Score
High risk| Evidence quality | 10/40 |
| Evidence consistency | 20/20 |
| Safety signals | 0/20 |
| Study recency | 10/10 |
| Evidence transparency | 10/10 |
Evidence Summary
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or systematic review)
- 0 studies identified benefits or no safety concern (GREEN)
- 10 studies reported limited or advisory safety evidence (YELLOW)
Evidence Policy
Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.
Last updated: 06 აპრ 2026, 12:11
Evidence Distribution
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Observational / other LOW evidence YELLOWBreeding Chlorophyll-Deficient Mutants of Chlorella vulgaris to Enhance Consumer Acceptance. ↗Olsen ML et al.. Breeding Chlorophyll-Deficient Mutants of Chlorella vulgaris to Enhance Consumer Acceptance.. Bioengineering (Basel). 2026. PMID:41899849.PMID 41899849 ↗Journal Bioengineering (Basel)Year 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41899849/
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Observational / other LOW evidence YELLOWApplication of Zinc Ferrite Nanoparticles for the Magnetic Removal of Algae That Bind Cadmium. ↗Koska P et al.. Application of Zinc Ferrite Nanoparticles for the Magnetic Removal of Algae That Bind Cadmium.. Nanomaterials (Basel). 2026. PMID:41893236.PMID 41893236 ↗Journal Nanomaterials (Basel)Year 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41893236/
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Observational / other LOW evidence YELLOWStatistical optimization of Chlorella vulgaris polysaccharides-mediated synthesis of platinum nanoparticles with dual functions: anticancer and anticoagulant activities. ↗Nour NS et al.. Statistical optimization of Chlorella vulgaris polysaccharides-mediated synthesis of platinum nanoparticles with dual functions: anticancer and anticoagulant activities.. Microb Cell Fact. 2026. PMID:41877117.PMID 41877117 ↗Journal Microb Cell FactYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41877117/
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Observational / other LOW evidence YELLOWPhotochemical synergy in hybrid sunscreen gels: enhanced UV protection and photostability with algal antioxidants, quercetin, azobenzene, and chitosan-coated TiOu2082 nanoparticles. ↗Shuheil MA et al.. Photochemical synergy in hybrid sunscreen gels: enhanced UV protection and photostability with algal antioxidants, quercetin, azobenzene, and chitosan-coated TiOu2082 nanoparticles.. Photochem Photobiol Sci. 2026. PMID:41870853.PMID 41870853 ↗Journal Photochem Photobiol SciYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41870853/
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Observational / other LOW evidence YELLOWExpression of the peanut diacylglycerol acyltransferase 3 increases the neutral lipid content and improves the fatty acid composition of Chlorella vulgaris. ↗Topf M et al.. Expression of the peanut diacylglycerol acyltransferase 3 increases the neutral lipid content and improves the fatty acid composition of Chlorella vulgaris.. Front Plant Sci. 2026. PMID:41868529.PMID 41868529 ↗Journal Front Plant SciYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41868529/
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Observational / other LOW evidence YELLOWRemoval of trace 17u03b1-ethinylestradiol by microalgal-bacterial granular sludge: The overlooked role of extracellular photosensitization. ↗Xue H et al.. Removal of trace 17u03b1-ethinylestradiol by microalgal-bacterial granular sludge: The overlooked role of extracellular photosensitization.. Environ Res. 2026. PMID:41864410.PMID 41864410 ↗Journal Environ ResYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41864410/
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Observational / other LOW evidence YELLOWMolecular-weight-dependent effects of humic acid on hexavalent chromium accumulation and reduction in green microalgae. ↗Luo L et al.. Molecular-weight-dependent effects of humic acid on hexavalent chromium accumulation and reduction in green microalgae.. J Hazard Mater. 2026. PMID:41846130.PMID 41846130 ↗Journal J Hazard MaterYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41846130/
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Observational / other LOW evidence YELLOWMicroalgae-Based Biostimulants Improve Biomass Production and Root-Linked Performance Stability in Pelargonium: A Three-Year Greenhouse Study. ↗Nu00e9meth A et al.. Microalgae-Based Biostimulants Improve Biomass Production and Root-Linked Performance Stability in Pelargonium: A Three-Year Greenhouse Study.. Plants (Basel). 2026. PMID:41829835.PMID 41829835 ↗Journal Plants (Basel)Year 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41829835/
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Observational / other LOW evidence YELLOWBiochemical and Antioxidant Characterization of Pigment-Deficient Chlorella vulgaris Flours and the Impact of Fermentation: Comparative Insights from Green, Honey, and White Variants. ↗Arouna N et al.. Biochemical and Antioxidant Characterization of Pigment-Deficient Chlorella vulgaris Flours and the Impact of Fermentation: Comparative Insights from Green, Honey, and White Variants.. Foods. 2026. PMID:41829228.PMID 41829228 ↗Journal FoodsYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41829228/
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Observational / other LOW evidence YELLOWConjugation of Microalgal Phenolics and Protein for Bioactivity and Bioaccessibility Enhancement. ↗Chen T et al.. Conjugation of Microalgal Phenolics and Protein for Bioactivity and Bioaccessibility Enhancement.. Foods. 2026. PMID:41829092.PMID 41829092 ↗Journal FoodsYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41829092/
Score Transparency
0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.
Method: Q = number of approved references ÷ 10 (capped at 1.0)
Limited — mostly case reports or animal studies
Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.
Mixed or neutral — roughly equal benefit and risk signals
Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.
One or more monitoring-level safety signals active
Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.
Final GIRI Score for Organic Chlorella. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
Full methodology & data sources
The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.
- References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
- Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
- Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
- Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
Risk Level Classification
Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.
0–3.0
3.0–5.5
5.5–7.5
7.5–10
The score pin shows exactly where this ingredient falls on the fixed risk scale.
What drove the Low classification for Organic Chlorella
A score of 2.0 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
0 approved references.
Limited — mostly case reports or animal studies (Level 4–5).
Neutral or mixed — benefit and risk signals roughly balanced.
No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.
No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).
How are the Low / Moderate / High / Critical thresholds defined?
The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:
| Level | Score | Meaning |
|---|---|---|
| LOW | 0.0 – 2.9 | Sparse or predominantly beneficial evidence. No active safety alerts. |
| MODERATE | 3.0 – 5.4 | Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups. |
| HIGH | 5.5 – 7.4 | Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended. |
| CRITICAL | 7.5 – 10 | Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision. |
Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.