ხუთშაბათი, აპრილი 16, 2026
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Global Ingredient Risk Index Specialty

Organic Chlorella

Chlorella vulgaris

Also known as: Chlorella, Chlorella vulgaris, Broken cell wall chlorella, Green algae chlorella

LOW RISK 2.0/10 How?

This ingredient is classified as unclassified risk.

02

Safety Profile

Information not yet available for this ingredient profile.

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03

Interactions

Information not yet available for this ingredient profile.

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04

Evidence and Scientific Findings

Overview

Ingredient Overview

Chlorella is a freshwater green algae used as a nutritional supplement for detoxification, immune support, and as a source of chlorophyll, vitamins, and minerals. Generally well tolerated. May cause green-colored stools. It binds heavy metals and can reduce warfarin efficacy (high Vitamin K content); monitor INR in patients on anticoagulants. Contamination with heavy metals or microcystins is a quality concern; choose tested, certified products. Photosensitivity reactions are rarely reported.

Classification

Biological and Chemical Classification

Scientific Name
Chlorella vulgaris
Mechanism

Mechanism of Action

Information not yet available for this ingredient profile.

Clinical Evidence

Clinical Evidence of Effectiveness

Information not yet available for this ingredient profile.

Pharmacokinetics

Pharmacokinetics

Information not yet available for this ingredient profile.

Dosage

Recommended Dosage

Information not yet available for this ingredient profile.

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05

SETI — Scientific Evidence Transparency Index

SETI Score 50/100
Risk Level High risk
Scientific Confidence Low
Evidence Strength Limited
Key Benefit Specialty
Evidence Reviewed 10 PubMed studies
Scientific Confidence Low
Based on study quality, consistency, and recency

Executive Summary — Ingredient Assessment

SETI Score 50/100
Risk Level High risk
Evidence Strength Limited
Main Benefit Specialty
Ingredient Organic Chlorella
Scientific name Chlorella vulgaris
Scientific Evidence Overview
  • 10 studies reviewed
  • 0 high-quality studies (meta-analysis or RCT)
  • Main clinical benefit observed: Specialty
  • Evidence consistency: High consistency across studies (100%)
Safety Signals
  • No significant safety signals identified in the reviewed literature.
Evidence Strength Limited
Final Scientific Assessment

The available scientific evidence for Organic Chlorella indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.

Ingredient Organic Chlorella
Evidence reviewed 10 peer-reviewed studies (last 10 years)
Scientific name Chlorella vulgaris
50 /100

Total SETI Score

High risk
Evidence quality 10/40
Evidence consistency 20/20
Safety signals 0/20
Study recency 10/10
Evidence transparency 10/10

Evidence Summary

  • 10 studies reviewed
  • 0 high-quality studies (meta-analysis or systematic review)
  • 0 studies identified benefits or no safety concern (GREEN)
  • 10 studies reported limited or advisory safety evidence (YELLOW)

Evidence Policy

Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.

Last updated: 06 აპრ 2026, 12:11

Evidence Distribution

10 Other / unclassified
  1. Observational / other LOW evidence YELLOW
    Breeding Chlorophyll-Deficient Mutants of Chlorella vulgaris to Enhance Consumer Acceptance. ↗
    PMID 41899849 ↗
    Journal Bioengineering (Basel)
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41899849/
    Olsen ML et al.. Breeding Chlorophyll-Deficient Mutants of Chlorella vulgaris to Enhance Consumer Acceptance.. Bioengineering (Basel). 2026. PMID:41899849.
  2. Observational / other LOW evidence YELLOW
    Application of Zinc Ferrite Nanoparticles for the Magnetic Removal of Algae That Bind Cadmium. ↗
    PMID 41893236 ↗
    Journal Nanomaterials (Basel)
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41893236/
    Koska P et al.. Application of Zinc Ferrite Nanoparticles for the Magnetic Removal of Algae That Bind Cadmium.. Nanomaterials (Basel). 2026. PMID:41893236.
  3. Observational / other LOW evidence YELLOW
    Statistical optimization of Chlorella vulgaris polysaccharides-mediated synthesis of platinum nanoparticles with dual functions: anticancer and anticoagulant activities. ↗
    PMID 41877117 ↗
    Journal Microb Cell Fact
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41877117/
    Nour NS et al.. Statistical optimization of Chlorella vulgaris polysaccharides-mediated synthesis of platinum nanoparticles with dual functions: anticancer and anticoagulant activities.. Microb Cell Fact. 2026. PMID:41877117.
  4. Observational / other LOW evidence YELLOW
    Photochemical synergy in hybrid sunscreen gels: enhanced UV protection and photostability with algal antioxidants, quercetin, azobenzene, and chitosan-coated TiOu2082 nanoparticles. ↗
    PMID 41870853 ↗
    Journal Photochem Photobiol Sci
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41870853/
    Shuheil MA et al.. Photochemical synergy in hybrid sunscreen gels: enhanced UV protection and photostability with algal antioxidants, quercetin, azobenzene, and chitosan-coated TiOu2082 nanoparticles.. Photochem Photobiol Sci. 2026. PMID:41870853.
  5. Observational / other LOW evidence YELLOW
    Expression of the peanut diacylglycerol acyltransferase 3 increases the neutral lipid content and improves the fatty acid composition of Chlorella vulgaris. ↗
    PMID 41868529 ↗
    Journal Front Plant Sci
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41868529/
    Topf M et al.. Expression of the peanut diacylglycerol acyltransferase 3 increases the neutral lipid content and improves the fatty acid composition of Chlorella vulgaris.. Front Plant Sci. 2026. PMID:41868529.
  6. Observational / other LOW evidence YELLOW
    Removal of trace 17u03b1-ethinylestradiol by microalgal-bacterial granular sludge: The overlooked role of extracellular photosensitization. ↗
    PMID 41864410 ↗
    Journal Environ Res
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41864410/
    Xue H et al.. Removal of trace 17u03b1-ethinylestradiol by microalgal-bacterial granular sludge: The overlooked role of extracellular photosensitization.. Environ Res. 2026. PMID:41864410.
  7. Observational / other LOW evidence YELLOW
    Molecular-weight-dependent effects of humic acid on hexavalent chromium accumulation and reduction in green microalgae. ↗
    PMID 41846130 ↗
    Journal J Hazard Mater
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41846130/
    Luo L et al.. Molecular-weight-dependent effects of humic acid on hexavalent chromium accumulation and reduction in green microalgae.. J Hazard Mater. 2026. PMID:41846130.
  8. Observational / other LOW evidence YELLOW
    Microalgae-Based Biostimulants Improve Biomass Production and Root-Linked Performance Stability in Pelargonium: A Three-Year Greenhouse Study. ↗
    PMID 41829835 ↗
    Journal Plants (Basel)
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41829835/
    Nu00e9meth A et al.. Microalgae-Based Biostimulants Improve Biomass Production and Root-Linked Performance Stability in Pelargonium: A Three-Year Greenhouse Study.. Plants (Basel). 2026. PMID:41829835.
  9. Observational / other LOW evidence YELLOW
    Biochemical and Antioxidant Characterization of Pigment-Deficient Chlorella vulgaris Flours and the Impact of Fermentation: Comparative Insights from Green, Honey, and White Variants. ↗
    PMID 41829228 ↗
    Journal Foods
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41829228/
    Arouna N et al.. Biochemical and Antioxidant Characterization of Pigment-Deficient Chlorella vulgaris Flours and the Impact of Fermentation: Comparative Insights from Green, Honey, and White Variants.. Foods. 2026. PMID:41829228.
  10. Observational / other LOW evidence YELLOW
    Conjugation of Microalgal Phenolics and Protein for Bioactivity and Bioaccessibility Enhancement. ↗
    PMID 41829092 ↗
    Journal Foods
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41829092/
    Chen T et al.. Conjugation of Microalgal Phenolics and Protein for Bioactivity and Bioaccessibility Enhancement.. Foods. 2026. PMID:41829092.
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06

Score Transparency

Q × L × D × S × 10 = 2.0 / 10

The GIRI Score is the product of four independently computed evidence components, each normalised to 0–1, then scaled to 0–10. Every component is derived exclusively from peer-reviewed references and regulatory data — no editorial judgement is applied.

Q
Evidence Quantity 0 / 10
0%

0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.

Method: Q = number of approved references ÷ 10 (capped at 1.0)

L
Evidence Quality 5 / 10
50%

Limited — mostly case reports or animal studies

Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.

D
Evidence Direction 5 / 10
Benefit
Risk
50%

Mixed or neutral — roughly equal benefit and risk signals

Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.

S
Safety Signals 5 / 10
50%

One or more monitoring-level safety signals active

Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.

0Q × 5L × 5D × 5S = 2.0 / 10

Final GIRI Score for Organic Chlorella. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

Full methodology & data sources

The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.

  • References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
  • Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
  • Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
  • Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
07

Risk Level Classification

LOW RISK 2.0/10

Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.

LOW
0–3.0
MODERATE
3.0–5.5
HIGH
5.5–7.5
CRITICAL
7.5–10
2.0

The score pin shows exactly where this ingredient falls on the fixed risk scale.

What drove the Low classification for Organic Chlorella

GIRI Score 2.0 / 10

A score of 2.0 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

Evidence Quantity (Q) 0 / 10 refs

0 approved references.

Evidence Quality (L) 50%

Limited — mostly case reports or animal studies (Level 4–5).

Evidence Direction (D) 50% toward risk

Neutral or mixed — benefit and risk signals roughly balanced.

Safety Signals (S) 0 active signals

No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.

Regulatory Status No restrictions found

No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).

How are the Low / Moderate / High / Critical thresholds defined?

The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:

LevelScoreMeaning
LOW0.0 – 2.9Sparse or predominantly beneficial evidence. No active safety alerts.
MODERATE3.0 – 5.4Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups.
HIGH5.5 – 7.4Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended.
CRITICAL7.5 – 10Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision.

Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.

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