ოთხშაბათი, აპრილი 15, 2026
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Global Ingredient Risk Index Specialty

Millet Seed Extract

Panicum miliaceum

Also known as: Proso millet extract, Millet extract

LOW RISK 1.0/10 How?

This ingredient is classified as unclassified risk (GIRI score: 1.0/10).

02

Safety Profile

Information not yet available for this ingredient profile.

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03

Interactions

Information not yet available for this ingredient profile.

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04

Evidence and Scientific Findings

Overview

Ingredient Overview

Millet seed extract is used in hair and nail supplements for its silica and cysteine content. It is very well tolerated with no significant adverse effects or drug interactions documented at standard doses.

Classification

Biological and Chemical Classification

Scientific Name
Panicum miliaceum
Mechanism

Mechanism of Action

Information not yet available for this ingredient profile.

Clinical Evidence

Clinical Evidence of Effectiveness

Information not yet available for this ingredient profile.

Pharmacokinetics

Pharmacokinetics

Information not yet available for this ingredient profile.

Dosage

Recommended Dosage

Information not yet available for this ingredient profile.

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05

SETI — Scientific Evidence Transparency Index

SETI Score 50/100
Risk Level High risk
Scientific Confidence Low
Evidence Strength Limited
Key Benefit Specialty
Evidence Reviewed 10 PubMed studies
Scientific Confidence Low
Based on study quality, consistency, and recency

Executive Summary — Ingredient Assessment

SETI Score 50/100
Risk Level High risk
Evidence Strength Limited
Main Benefit Specialty
Ingredient Millet Seed Extract
Scientific name Panicum miliaceum
Scientific Evidence Overview
  • 10 studies reviewed
  • 0 high-quality studies (meta-analysis or RCT)
  • Main clinical benefit observed: Specialty
  • Evidence consistency: High consistency across studies (100%)
Safety Signals
  • No significant safety signals identified in the reviewed literature.
Evidence Strength Limited
Final Scientific Assessment

The available scientific evidence for Millet Seed Extract indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.

Ingredient Millet Seed Extract
Evidence reviewed 10 peer-reviewed studies (last 10 years)
Scientific name Panicum miliaceum
50 /100

Total SETI Score

High risk
Evidence quality 10/40
Evidence consistency 20/20
Safety signals 0/20
Study recency 10/10
Evidence transparency 10/10

Evidence Summary

  • 10 studies reviewed
  • 0 high-quality studies (meta-analysis or systematic review)
  • 0 studies identified benefits or no safety concern (GREEN)
  • 10 studies reported limited or advisory safety evidence (YELLOW)

Evidence Policy

Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.

Last updated: 26 მარ 2026, 14:37

Evidence Distribution

10 Other / unclassified
  1. Observational / other LOW evidence YELLOW
    Exploring the diversity of the CO2-concentrating mechanism (CCM) in different C4 subtypes. ↗
    PMID 41777160 ↗
    Journal J Exp Bot
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41777160/
    Baccolini C et al.. Exploring the diversity of the CO2-concentrating mechanism (CCM) in different C4 subtypes.. J Exp Bot. 2026. PMID:41777160.
  2. Observational / other LOW evidence YELLOW
    Earliest millet cultivation reflects steppe connections, dietary flexibility, and resilience in Bronze Age northern Greece. ↗
    PMID 41774731 ↗
    Journal PLoS One
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41774731/
    Karanikola K et al.. Earliest millet cultivation reflects steppe connections, dietary flexibility, and resilience in Bronze Age northern Greece.. PLoS One. 2026. PMID:41774731.
  3. Observational / other LOW evidence YELLOW
    Genome-wide identification and drought-responsive root expression profiling of the VQ gene family in proso millet (Panicum miliaceum L.). ↗
    PMID 41695714 ↗
    Journal PeerJ
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41695714/
    Tan Q et al.. Genome-wide identification and drought-responsive root expression profiling of the VQ gene family in proso millet (Panicum miliaceum L.).. PeerJ. 2026. PMID:41695714.
  4. Observational / other LOW evidence YELLOW
    Flavor quality during fermentation of the specialty product proso millet (Panicum miliaceum L.) thick wine: Insights from microbiome and metabolomics analyses. ↗
    PMID 41360535 ↗
    Journal Food Res Int
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41360535/
    Wang H et al.. Flavor quality during fermentation of the specialty product proso millet (Panicum miliaceum L.) thick wine: Insights from microbiome and metabolomics analyses.. Food Res Int. 2026. PMID:41360535.
  5. Observational / other LOW evidence YELLOW
    Research note: Proso millet as an alternative grain source in white leghorn pullet diets. ↗
    PMID 41260087 ↗
    Journal Poult Sci
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41260087/
    Purdum S et al.. Research note: Proso millet as an alternative grain source in white leghorn pullet diets.. Poult Sci. 2026. PMID:41260087.
  6. Observational / other LOW evidence YELLOW
    Pyrene distribution dynamics and its possible degradation pathways in proso millet tissues: an experimental approach. ↗
    PMID 41223087 ↗
    Journal Int J Phytoremediation
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41223087/
    Tarigholizadeh S et al.. Pyrene distribution dynamics and its possible degradation pathways in proso millet tissues: an experimental approach.. Int J Phytoremediation. 2026. PMID:41223087.
  7. Observational / other LOW evidence YELLOW
    Thermal desorption GC/MS on human dental calculus detected minute millet consumption in medieval Ukraine. ↗
    PMID 41360916 ↗
    Journal Sci Rep
    Year 2025
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41360916/
    Shoda S et al.. Thermal desorption GC/MS on human dental calculus detected minute millet consumption in medieval Ukraine.. Sci Rep. 2025. PMID:41360916.
  8. Observational / other LOW evidence YELLOW
    Genome-wide identification and expression analysis of the MBD gene family in Broomcorn millet (Panicum miliaceum) and its response to abiotic stress. ↗
    PMID 41188717 ↗
    Journal BMC Genomics
    Year 2025
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41188717/
    Xu Y et al.. Genome-wide identification and expression analysis of the MBD gene family in Broomcorn millet (Panicum miliaceum) and its response to abiotic stress.. BMC Genomics. 2025. PMID:41188717.
  9. Observational / other LOW evidence YELLOW
    Modulating effects of herbicide-safener co-application on rhizosphere microbiota and soil function in proso millet (Panicum miliaceum L.). ↗
    PMID 41175754 ↗
    Journal J Hazard Mater
    Year 2025
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41175754/
    Feng Y et al.. Modulating effects of herbicide-safener co-application on rhizosphere microbiota and soil function in proso millet (Panicum miliaceum L.).. J Hazard Mater. 2025. PMID:41175754.
  10. Observational / other LOW evidence YELLOW
    Bioprospecting and mode of action of volatile organic compounds from morphospecies of the endophytic fungus Hypoxylon anthochroum in the field of bioherbicides. ↗
    PMID 41082008 ↗
    Journal World J Microbiol Biotechnol
    Year 2025
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41082008/
    Roque-Flores G et al.. Bioprospecting and mode of action of volatile organic compounds from morphospecies of the endophytic fungus Hypoxylon anthochroum in the field of bioherbicides.. World J Microbiol Biotechnol. 2025. PMID:41082008.
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06

Score Transparency

Q × L × D × S × 10 = 1.0 / 10

The GIRI Score is the product of four independently computed evidence components, each normalised to 0–1, then scaled to 0–10. Every component is derived exclusively from peer-reviewed references and regulatory data — no editorial judgement is applied.

Q
Evidence Quantity 0 / 10
0%

0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.

Method: Q = number of approved references ÷ 10 (capped at 1.0)

L
Evidence Quality 5 / 10
50%

Limited — mostly case reports or animal studies

Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.

D
Evidence Direction 5 / 10
Benefit
Risk
50%

Mixed or neutral — roughly equal benefit and risk signals

Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.

S
Safety Signals 5 / 10
50%

One or more monitoring-level safety signals active

Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.

0Q × 5L × 5D × 5S = 1.0 / 10

Final GIRI Score for Millet Seed Extract. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

Full methodology & data sources

The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.

  • References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
  • Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
  • Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
  • Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
07

Risk Level Classification

LOW RISK 1.0/10

Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.

LOW
0–3.0
MODERATE
3.0–5.5
HIGH
5.5–7.5
CRITICAL
7.5–10
1.0

The score pin shows exactly where this ingredient falls on the fixed risk scale.

What drove the Low classification for Millet Seed Extract

GIRI Score 1.0 / 10

A score of 1.0 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

Evidence Quantity (Q) 0 / 10 refs

0 approved references.

Evidence Quality (L) 50%

Limited — mostly case reports or animal studies (Level 4–5).

Evidence Direction (D) 50% toward risk

Neutral or mixed — benefit and risk signals roughly balanced.

Safety Signals (S) 0 active signals

No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.

Regulatory Status No restrictions found

No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).

How are the Low / Moderate / High / Critical thresholds defined?

The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:

LevelScoreMeaning
LOW0.0 – 2.9Sparse or predominantly beneficial evidence. No active safety alerts.
MODERATE3.0 – 5.4Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups.
HIGH5.5 – 7.4Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended.
CRITICAL7.5 – 10Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision.

Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.

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