Safety Profile
Known Safety Concerns
- Avoid in severe immunocompromise or sepsis risk
- Temporary bloating during gut microbiome adjustment
- Very few adverse events in clinical trials
- One of the best-studied and safest probiotic strains
Contraindications
- Avoid in severe immunocompromise or sepsis risk
- Temporary bloating during gut microbiome adjustment
Interactions
Information not yet available for this ingredient profile.
Evidence and Scientific Findings
Ingredient Overview
Lactobacillus plantarum is one of the most versatile and studied probiotic strains with evidence for IBS symptom reduction, gut barrier function, and immune support. Strain 299v has the strongest evidence base. Generally very safe. Caution in severe immunocompromise.
Biological and Chemical Classification
- Scientific Name
- Lactiplantibacillus plantarum (Lactobacillus plantarum)
Mechanism of Action
Information not yet available for this ingredient profile.
Clinical Evidence of Effectiveness
Information not yet available for this ingredient profile.
Pharmacokinetics
Information not yet available for this ingredient profile.
Recommended Dosage
Information not yet available for this ingredient profile.
SETI — Scientific Evidence Transparency Index
Executive Summary — Ingredient Assessment
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or RCT)
- Main clinical benefit observed: Probiotic
- Evidence consistency: High consistency across studies (100%)
- Avoid in severe immunocompromise or sepsis risk
- Temporary bloating during gut microbiome adjustment
- Very few adverse events in clinical trials
- One of the best-studied and safest probiotic strains
The available scientific evidence for Lactobacillus Plantarum indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.
Total SETI Score
High risk| Evidence quality | 10/40 |
| Evidence consistency | 20/20 |
| Safety signals | 0/20 |
| Study recency | 10/10 |
| Evidence transparency | 10/10 |
Evidence Summary
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or systematic review)
- 0 studies identified benefits or no safety concern (GREEN)
- 10 studies reported limited or advisory safety evidence (YELLOW)
Evidence Policy
Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.
Last updated: 25 მარ 2026, 12:57
Evidence Distribution
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Observational / other LOW evidence YELLOWSynergistic modification of phycocyanin by Lactobacillus plantarum and protease: Physicochemical properties, structural characteristics, and flavor profiles. ↗Wang Y et al.. Synergistic modification of phycocyanin by Lactobacillus plantarum and protease: Physicochemical properties, structural characteristics, and flavor profiles.. Food Chem. 2026. PMID:41875775.PMID 41875775 ↗Journal Food ChemYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41875775/
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Observational / other LOW evidence YELLOWEffect of probiotic and synbiotic administration on the nutritional status of hemodialysis patients: a randomized-controlled trial. ↗Saad WM et al.. Effect of probiotic and synbiotic administration on the nutritional status of hemodialysis patients: a randomized-controlled trial.. Int Urol Nephrol. 2026. PMID:41872650.PMID 41872650 ↗Journal Int Urol NephrolYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41872650/
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Observational / other LOW evidence YELLOWImprovement of starch fine structure, physicochemical properties and digestive characteristics of adlay seeds by fermentation with Lactobacillus plantarum and Lactobacillus paracasei. ↗Xu S et al.. Improvement of starch fine structure, physicochemical properties and digestive characteristics of adlay seeds by fermentation with Lactobacillus plantarum and Lactobacillus paracasei.. Int J Biol Macromol. 2026. PMID:41861878.PMID 41861878 ↗Journal Int J Biol MacromolYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41861878/
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Observational / other LOW evidence YELLOWMoisture and interspecies interactions shape microbial communities and metabolites to define the sensory profile of fermented sausages. ↗Zhang D et al.. Moisture and interspecies interactions shape microbial communities and metabolites to define the sensory profile of fermented sausages.. Food Chem. 2026. PMID:41855829.PMID 41855829 ↗Journal Food ChemYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41855829/
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Observational / other LOW evidence YELLOWCharacterization and application of immobilized Lactobacillus plantarum fiber powder as a probiotic starter culture for Thai-fermented pork. ↗Tangwatcharin P et al.. Characterization and application of immobilized Lactobacillus plantarum fiber powder as a probiotic starter culture for Thai-fermented pork.. Food Sci Anim Resour. 2026. PMID:41849082.PMID 41849082 ↗Journal Food Sci Anim ResourYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41849082/
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Observational / other LOW evidence YELLOWFermented Tenebrio molitor larvae extract with Lactobacillus plantarum ameliorates dexamethasone-induced muscle atrophy in vitro and in vivo. ↗Kim SV et al.. Fermented Tenebrio molitor larvae extract with Lactobacillus plantarum ameliorates dexamethasone-induced muscle atrophy in vitro and in vivo.. Food Sci Anim Resour. 2026. PMID:41848990.PMID 41848990 ↗Journal Food Sci Anim ResourYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41848990/
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Observational / other LOW evidence YELLOWLactobacillus plantarum M3 Fermentation Enhances Mulberry Juice Antioxidant Capacity: Metabolomic Analysis. ↗Zhong XS et al.. Lactobacillus plantarum M3 Fermentation Enhances Mulberry Juice Antioxidant Capacity: Metabolomic Analysis.. Foods. 2026. PMID:41829179.PMID 41829179 ↗Journal FoodsYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41829179/
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Observational / other LOW evidence YELLOWEnzymatic Synergy-Driven Biotransformation Generates a Postbiotic-Rich Functional Matrix That Reprograms Gut Microbiota Metabolic Pathways Under Stress Conditions. ↗Chen J et al.. Enzymatic Synergy-Driven Biotransformation Generates a Postbiotic-Rich Functional Matrix That Reprograms Gut Microbiota Metabolic Pathways Under Stress Conditions.. Int J Mol Sci. 2026. PMID:41828538.PMID 41828538 ↗Journal Int J Mol SciYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41828538/
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Observational / other LOW evidence YELLOWLong-term capsaicin intake and gut inflammation: microbial alterations, metabolic mechanisms, and intervention effects. ↗Zhu L et al.. Long-term capsaicin intake and gut inflammation: microbial alterations, metabolic mechanisms, and intervention effects.. Food Res Int. 2026. PMID:41819938.PMID 41819938 ↗Journal Food Res IntYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41819938/
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Observational / other LOW evidence YELLOWProbiotic Therapy with Lactobacillus Restores Gut Microbiota and Modulates Immunity in Salmonella-Infected Mice. ↗Junaid M et al.. Probiotic Therapy with Lactobacillus Restores Gut Microbiota and Modulates Immunity in Salmonella-Infected Mice.. Foodborne Pathog Dis. 2026. PMID:41810566.PMID 41810566 ↗Journal Foodborne Pathog DisYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41810566/
Score Transparency
0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.
Method: Q = number of approved references ÷ 10 (capped at 1.0)
Limited — mostly case reports or animal studies
Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.
Mixed or neutral — roughly equal benefit and risk signals
Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.
One or more monitoring-level safety signals active
Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.
Final GIRI Score for Lactobacillus Plantarum. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
Full methodology & data sources
The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.
- References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
- Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
- Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
- Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
Risk Level Classification
Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.
0–3.0
3.0–5.5
5.5–7.5
7.5–10
The score pin shows exactly where this ingredient falls on the fixed risk scale.
What drove the Low classification for Lactobacillus Plantarum
A score of 2.0 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
0 approved references.
Limited — mostly case reports or animal studies (Level 4–5).
Neutral or mixed — benefit and risk signals roughly balanced.
No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.
No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).
How are the Low / Moderate / High / Critical thresholds defined?
The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:
| Level | Score | Meaning |
|---|---|---|
| LOW | 0.0 – 2.9 | Sparse or predominantly beneficial evidence. No active safety alerts. |
| MODERATE | 3.0 – 5.4 | Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups. |
| HIGH | 5.5 – 7.4 | Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended. |
| CRITICAL | 7.5 – 10 | Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision. |
Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.