Safety Profile
Information not yet available for this ingredient profile.
Interactions
Information not yet available for this ingredient profile.
Evidence and Scientific Findings
Ingredient Overview
Juniper berry extract has diuretic and antimicrobial properties. It is generally safe for short-term use. It can irritate the kidneys with prolonged use and should be avoided in kidney disease. It is contraindicated in pregnancy due to possible uterotonic effects. May interact with diuretics and lithium.
Biological and Chemical Classification
- Scientific Name
- Juniperus communis
Mechanism of Action
Information not yet available for this ingredient profile.
Clinical Evidence of Effectiveness
Information not yet available for this ingredient profile.
Pharmacokinetics
Information not yet available for this ingredient profile.
Recommended Dosage
Information not yet available for this ingredient profile.
SETI — Scientific Evidence Transparency Index
Executive Summary — Ingredient Assessment
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or RCT)
- Main clinical benefit observed: Botanical
- Evidence consistency: High consistency across studies (100%)
- No significant safety signals identified in the reviewed literature.
The available scientific evidence for Juniper Berry Extract indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.
Total SETI Score
High risk| Evidence quality | 10/40 |
| Evidence consistency | 20/20 |
| Safety signals | 0/20 |
| Study recency | 10/10 |
| Evidence transparency | 10/10 |
Evidence Summary
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or systematic review)
- 0 studies identified benefits or no safety concern (GREEN)
- 10 studies reported limited or advisory safety evidence (YELLOW)
Evidence Policy
Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.
Last updated: 26 მარ 2026, 14:36
Evidence Distribution
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Observational / other LOW evidence YELLOWNaOH-Only Pretreated Wood Densification: A Simplified Sulfite-Free Route Across Wood Species. ↗Andze L et al.. NaOH-Only Pretreated Wood Densification: A Simplified Sulfite-Free Route Across Wood Species.. Polymers (Basel). 2026. PMID:41682020.PMID 41682020 ↗Journal Polymers (Basel)Year 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41682020/
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Observational / other LOW evidence YELLOWApplication of juniper (Juniperus communis) essential oil nanoemulsions to control spoilage and pathogenic bacteria in fish. ↗u00c7olak H et al.. Application of juniper (Juniperus communis) essential oil nanoemulsions to control spoilage and pathogenic bacteria in fish.. Front Microbiol. 2026. PMID:41657903.PMID 41657903 ↗Journal Front MicrobiolYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41657903/
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Observational / other LOW evidence YELLOWReduced snow cover at the alpine treeline: resistance and recovery of saplings. ↗Charra-Vaskou K et al.. Reduced snow cover at the alpine treeline: resistance and recovery of saplings.. New Phytol. 2026. PMID:41635117.PMID 41635117 ↗Journal New PhytolYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41635117/
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Observational / other LOW evidence YELLOWLC-MS/MS characterization, biological activity, and carbonic anhydrase inhibitory potential of five medicinal plant extracts from Romania and Tu00fcrkiye. ↗Bu00fcker E et al.. LC-MS/MS characterization, biological activity, and carbonic anhydrase inhibitory potential of five medicinal plant extracts from Romania and Tu00fcrkiye.. Sci Rep. 2026. PMID:41634376.PMID 41634376 ↗Journal Sci RepYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41634376/
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Observational / other LOW evidence YELLOWJuniperus communis L. Needle Extract Modulates Oxidative and Inflammatory Pathways in an Experimental Model of Acute Inflammation. ↗Bolunduu021b D et al.. Juniperus communis L. Needle Extract Modulates Oxidative and Inflammatory Pathways in an Experimental Model of Acute Inflammation.. Molecules. 2026. PMID:41599297.PMID 41599297 ↗Journal MoleculesYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41599297/
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Observational / other LOW evidence YELLOW500-year paleoclimate record inferred from Greenland Juniper wood contextualizes current climate warming. ↗Opau0142a-Owczarek M et al.. 500-year paleoclimate record inferred from Greenland Juniper wood contextualizes current climate warming.. Nat Commun. 2025. PMID:41298452.PMID 41298452 ↗Journal Nat CommunYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41298452/
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Observational / other LOW evidence YELLOWShrubs and trees as natural insect protection for grazing animals in Switzerland and the alpine region: A systematic review of in vitro,… ↗Schlittenlacher T et al.. Shrubs and trees as natural insect protection for grazing animals in Switzerland and the alpine region: A systematic review of in vitro, in vivo and clinical trials.. Med Vet Entomol. 2025. PMID:41257434.PMID 41257434 ↗Journal Med Vet EntomolYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41257434/
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Observational / other LOW evidence YELLOWEfficacy and safety of Rolecau00ae juniper 100 mg in the treatment of functional dyspepsia: A randomized, double-blind, placebo-controlled trial. ↗Albrecht U et al.. Efficacy and safety of Rolecau00ae juniper 100 mg in the treatment of functional dyspepsia: A randomized, double-blind, placebo-controlled trial.. Phytomedicine. 2025. PMID:41240546.PMID 41240546 ↗Journal PhytomedicineYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41240546/
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Observational / other LOW evidence YELLOWAssessment of mineral nutrition level and heavy metals toxicity in Kosovo herbal remedies. ↗Milaimi A et al.. Assessment of mineral nutrition level and heavy metals toxicity in Kosovo herbal remedies.. J Environ Sci Health B. 2025. PMID:41086102.PMID 41086102 ↗Journal J Environ Sci Health BYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41086102/
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Observational / other LOW evidence YELLOWInvestigation of Antiparasitic Effect of Juniperus communis L. Fruits Extracts. ↗u00c7avuu015f u0130 et al.. Investigation of Antiparasitic Effect of Juniperus communis L. Fruits Extracts.. Turkiye Parazitol Derg. 2025. PMID:40923470.PMID 40923470 ↗Journal Turkiye Parazitol DergYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40923470/
Score Transparency
0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.
Method: Q = number of approved references ÷ 10 (capped at 1.0)
Limited — mostly case reports or animal studies
Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.
Mixed or neutral — roughly equal benefit and risk signals
Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.
One or more monitoring-level safety signals active
Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.
Final GIRI Score for Juniper Berry Extract. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
Full methodology & data sources
The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.
- References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
- Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
- Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
- Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
Risk Level Classification
Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.
0–3.0
3.0–5.5
5.5–7.5
7.5–10
The score pin shows exactly where this ingredient falls on the fixed risk scale.
What drove the Low classification for Juniper Berry Extract
A score of 2.5 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
0 approved references.
Limited — mostly case reports or animal studies (Level 4–5).
Neutral or mixed — benefit and risk signals roughly balanced.
No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.
No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).
How are the Low / Moderate / High / Critical thresholds defined?
The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:
| Level | Score | Meaning |
|---|---|---|
| LOW | 0.0 – 2.9 | Sparse or predominantly beneficial evidence. No active safety alerts. |
| MODERATE | 3.0 – 5.4 | Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups. |
| HIGH | 5.5 – 7.4 | Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended. |
| CRITICAL | 7.5 – 10 | Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision. |
Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.