ოთხშაბათი, აპრილი 15, 2026
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Global Ingredient Risk Index Botanical

Juniper Berry Extract

Juniperus communis

Also known as: Common juniper extract, Juniperus communis berry

LOW RISK 2.5/10 How?

This ingredient is classified as unclassified risk (GIRI score: 2.5/10).

02

Safety Profile

Information not yet available for this ingredient profile.

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03

Interactions

Information not yet available for this ingredient profile.

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04

Evidence and Scientific Findings

Overview

Ingredient Overview

Juniper berry extract has diuretic and antimicrobial properties. It is generally safe for short-term use. It can irritate the kidneys with prolonged use and should be avoided in kidney disease. It is contraindicated in pregnancy due to possible uterotonic effects. May interact with diuretics and lithium.

Classification

Biological and Chemical Classification

Scientific Name
Juniperus communis
Mechanism

Mechanism of Action

Information not yet available for this ingredient profile.

Clinical Evidence

Clinical Evidence of Effectiveness

Information not yet available for this ingredient profile.

Pharmacokinetics

Pharmacokinetics

Information not yet available for this ingredient profile.

Dosage

Recommended Dosage

Information not yet available for this ingredient profile.

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05

SETI — Scientific Evidence Transparency Index

SETI Score 50/100
Risk Level High risk
Scientific Confidence Low
Evidence Strength Limited
Key Benefit Botanical
Evidence Reviewed 10 PubMed studies
Scientific Confidence Low
Based on study quality, consistency, and recency

Executive Summary — Ingredient Assessment

SETI Score 50/100
Risk Level High risk
Evidence Strength Limited
Main Benefit Botanical
Ingredient Juniper Berry Extract
Scientific name Juniperus communis
Scientific Evidence Overview
  • 10 studies reviewed
  • 0 high-quality studies (meta-analysis or RCT)
  • Main clinical benefit observed: Botanical
  • Evidence consistency: High consistency across studies (100%)
Safety Signals
  • No significant safety signals identified in the reviewed literature.
Evidence Strength Limited
Final Scientific Assessment

The available scientific evidence for Juniper Berry Extract indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.

Ingredient Juniper Berry Extract
Evidence reviewed 10 peer-reviewed studies (last 10 years)
Scientific name Juniperus communis
50 /100

Total SETI Score

High risk
Evidence quality 10/40
Evidence consistency 20/20
Safety signals 0/20
Study recency 10/10
Evidence transparency 10/10

Evidence Summary

  • 10 studies reviewed
  • 0 high-quality studies (meta-analysis or systematic review)
  • 0 studies identified benefits or no safety concern (GREEN)
  • 10 studies reported limited or advisory safety evidence (YELLOW)

Evidence Policy

Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.

Last updated: 26 მარ 2026, 14:36

Evidence Distribution

10 Other / unclassified
  1. Observational / other LOW evidence YELLOW
    NaOH-Only Pretreated Wood Densification: A Simplified Sulfite-Free Route Across Wood Species. ↗
    PMID 41682020 ↗
    Journal Polymers (Basel)
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41682020/
    Andze L et al.. NaOH-Only Pretreated Wood Densification: A Simplified Sulfite-Free Route Across Wood Species.. Polymers (Basel). 2026. PMID:41682020.
  2. Observational / other LOW evidence YELLOW
    Application of juniper (Juniperus communis) essential oil nanoemulsions to control spoilage and pathogenic bacteria in fish. ↗
    PMID 41657903 ↗
    Journal Front Microbiol
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41657903/
    u00c7olak H et al.. Application of juniper (Juniperus communis) essential oil nanoemulsions to control spoilage and pathogenic bacteria in fish.. Front Microbiol. 2026. PMID:41657903.
  3. Observational / other LOW evidence YELLOW
    Reduced snow cover at the alpine treeline: resistance and recovery of saplings. ↗
    PMID 41635117 ↗
    Journal New Phytol
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41635117/
    Charra-Vaskou K et al.. Reduced snow cover at the alpine treeline: resistance and recovery of saplings.. New Phytol. 2026. PMID:41635117.
  4. Observational / other LOW evidence YELLOW
    LC-MS/MS characterization, biological activity, and carbonic anhydrase inhibitory potential of five medicinal plant extracts from Romania and Tu00fcrkiye. ↗
    PMID 41634376 ↗
    Journal Sci Rep
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41634376/
    Bu00fcker E et al.. LC-MS/MS characterization, biological activity, and carbonic anhydrase inhibitory potential of five medicinal plant extracts from Romania and Tu00fcrkiye.. Sci Rep. 2026. PMID:41634376.
  5. Observational / other LOW evidence YELLOW
    Juniperus communis L. Needle Extract Modulates Oxidative and Inflammatory Pathways in an Experimental Model of Acute Inflammation. ↗
    PMID 41599297 ↗
    Journal Molecules
    Year 2026
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41599297/
    Bolunduu021b D et al.. Juniperus communis L. Needle Extract Modulates Oxidative and Inflammatory Pathways in an Experimental Model of Acute Inflammation.. Molecules. 2026. PMID:41599297.
  6. Observational / other LOW evidence YELLOW
    500-year paleoclimate record inferred from Greenland Juniper wood contextualizes current climate warming. ↗
    PMID 41298452 ↗
    Journal Nat Commun
    Year 2025
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41298452/
    Opau0142a-Owczarek M et al.. 500-year paleoclimate record inferred from Greenland Juniper wood contextualizes current climate warming.. Nat Commun. 2025. PMID:41298452.
  7. Observational / other LOW evidence YELLOW
    Shrubs and trees as natural insect protection for grazing animals in Switzerland and the alpine region: A systematic review of in vitro,… ↗
    PMID 41257434 ↗
    Journal Med Vet Entomol
    Year 2025
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41257434/
    Schlittenlacher T et al.. Shrubs and trees as natural insect protection for grazing animals in Switzerland and the alpine region: A systematic review of in vitro, in vivo and clinical trials.. Med Vet Entomol. 2025. PMID:41257434.
  8. Observational / other LOW evidence YELLOW
    Efficacy and safety of Rolecau00ae juniper 100 mg in the treatment of functional dyspepsia: A randomized, double-blind, placebo-controlled trial. ↗
    PMID 41240546 ↗
    Journal Phytomedicine
    Year 2025
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41240546/
    Albrecht U et al.. Efficacy and safety of Rolecau00ae juniper 100 mg in the treatment of functional dyspepsia: A randomized, double-blind, placebo-controlled trial.. Phytomedicine. 2025. PMID:41240546.
  9. Observational / other LOW evidence YELLOW
    Assessment of mineral nutrition level and heavy metals toxicity in Kosovo herbal remedies. ↗
    PMID 41086102 ↗
    Journal J Environ Sci Health B
    Year 2025
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/41086102/
    Milaimi A et al.. Assessment of mineral nutrition level and heavy metals toxicity in Kosovo herbal remedies.. J Environ Sci Health B. 2025. PMID:41086102.
  10. Observational / other LOW evidence YELLOW
    Investigation of Antiparasitic Effect of Juniperus communis L. Fruits Extracts. ↗
    PMID 40923470 ↗
    Journal Turkiye Parazitol Derg
    Year 2025
    Study type Observational / other
    Evidence strength LOW evidence
    PubMed link https://pubmed.ncbi.nlm.nih.gov/40923470/
    u00c7avuu015f u0130 et al.. Investigation of Antiparasitic Effect of Juniperus communis L. Fruits Extracts.. Turkiye Parazitol Derg. 2025. PMID:40923470.
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06

Score Transparency

Q × L × D × S × 10 = 2.5 / 10

The GIRI Score is the product of four independently computed evidence components, each normalised to 0–1, then scaled to 0–10. Every component is derived exclusively from peer-reviewed references and regulatory data — no editorial judgement is applied.

Q
Evidence Quantity 0 / 10
0%

0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.

Method: Q = number of approved references ÷ 10 (capped at 1.0)

L
Evidence Quality 5 / 10
50%

Limited — mostly case reports or animal studies

Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.

D
Evidence Direction 5 / 10
Benefit
Risk
50%

Mixed or neutral — roughly equal benefit and risk signals

Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.

S
Safety Signals 5 / 10
50%

One or more monitoring-level safety signals active

Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.

0Q × 5L × 5D × 5S = 2.5 / 10

Final GIRI Score for Juniper Berry Extract. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

Full methodology & data sources

The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.

  • References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
  • Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
  • Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
  • Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
07

Risk Level Classification

LOW RISK 2.5/10

Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.

LOW
0–3.0
MODERATE
3.0–5.5
HIGH
5.5–7.5
CRITICAL
7.5–10
2.5

The score pin shows exactly where this ingredient falls on the fixed risk scale.

What drove the Low classification for Juniper Berry Extract

GIRI Score 2.5 / 10

A score of 2.5 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

Evidence Quantity (Q) 0 / 10 refs

0 approved references.

Evidence Quality (L) 50%

Limited — mostly case reports or animal studies (Level 4–5).

Evidence Direction (D) 50% toward risk

Neutral or mixed — benefit and risk signals roughly balanced.

Safety Signals (S) 0 active signals

No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.

Regulatory Status No restrictions found

No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).

How are the Low / Moderate / High / Critical thresholds defined?

The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:

LevelScoreMeaning
LOW0.0 – 2.9Sparse or predominantly beneficial evidence. No active safety alerts.
MODERATE3.0 – 5.4Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups.
HIGH5.5 – 7.4Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended.
CRITICAL7.5 – 10Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision.

Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.

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