Global Ingredient Risk Index Botanical

Griffonia Simplicifolia

Griffonia simplicifolia (seed extract)

Also known as: 5-HTP source, Griffonia seed, African black bean

25 მარ 2026

MODERATE RISK 5.0/10 How?

This ingredient is classified as unclassified risk (GIRI score: 5.0/10).

Known Safety Concerns

Serotonin syndrome risk with SSRIs, SNRIs, MAOIs, triptans
Contraindicated with MAO inhibitors
Eosinophilia-myalgia syndrome risk with contaminants
Contains 5-HTP -- all 5-HTP safety concerns apply

Contraindications

Serotonin syndrome risk with SSRIs, SNRIs, MAOIs, triptans
Contraindicated with MAO inhibitors

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Information not yet available for this ingredient profile.

Griffonia simplicifolia seeds are the primary commercial source of 5-HTP. Safety issues are those of 5-HTP itself: serotonin syndrome risk when combined with serotonergic medications (SSRIs, SNRIs, MAOIs, triptans). Should not be used within 2 weeks of MAOIs.

Scientific Name: Griffonia simplicifolia (seed extract)

Information not yet available for this ingredient profile.

SETI Score 50/100

Risk Level High risk

Scientific Confidence Low

Evidence Strength Limited

Key Benefit Botanical

Key Safety Concern Serotonin syndrome risk with SSRIs, SNRIs, MAOIs, triptans

Evidence Reviewed 10 PubMed studies

Scientific Confidence Low

Based on study quality, consistency, and recency

Executive Summary — Ingredient Assessment

SETI Score 50/100

Risk Level High risk

Evidence Strength Limited

Main Benefit Botanical

Main Safety Concern Serotonin syndrome risk with SSRIs, SNRIs, MAOIs, triptans

Ingredient Griffonia Simplicifolia

Scientific name Griffonia simplicifolia (seed extract)

Scientific Evidence Overview

10 studies reviewed
0 high-quality studies (meta-analysis or RCT)
Main clinical benefit observed: Botanical
Evidence consistency: High consistency across studies (100%)

Safety Signals

Serotonin syndrome risk with SSRIs, SNRIs, MAOIs, triptans
Contraindicated with MAO inhibitors
Eosinophilia-myalgia syndrome risk with contaminants
Contains 5-HTP -- all 5-HTP safety concerns apply

Evidence Strength Limited

Final Scientific Assessment

The available scientific evidence for Griffonia Simplicifolia indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.

Ingredient Griffonia Simplicifolia

Evidence reviewed 10 peer-reviewed studies (last 10 years)

Scientific name Griffonia simplicifolia (seed extract)

50 /100

Total SETI Score

High risk

Evidence quality	10/40
Evidence consistency	20/20
Safety signals	0/20
Study recency	10/10
Evidence transparency	10/10

Evidence Summary

10 studies reviewed
0 high-quality studies (meta-analysis or systematic review)
0 studies identified benefits or no safety concern (GREEN)
10 studies reported limited or advisory safety evidence (YELLOW)

Evidence Policy

Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.

Last updated: 25 მარ 2026, 22:38

Evidence Distribution

10 Other / unclassified

Observational / other LOW evidence YELLOW
Antimetastatic Effects of a Griffonia simplicifolia Seed Extract in Osteosarcoma Cell Lines. ↗

PMID 41750643 ↗

Journal Antioxidants (Basel)

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41750643/

Bellavia D et al.. Antimetastatic Effects of a Griffonia simplicifolia Seed Extract in Osteosarcoma Cell Lines.. Antioxidants (Basel). 2026. PMID:41750643.
Observational / other LOW evidence YELLOW
Modulation of macrophage polarization with acute administration of Vericiguat after myocardial infarction. ↗

PMID 41693664 ↗

Journal Am J Physiol Heart Circ Physiol

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41693664/

Dempster T et al.. Modulation of macrophage polarization with acute administration of Vericiguat after myocardial infarction.. Am J Physiol Heart Circ Physiol. 2026. PMID:41693664.
Observational / other LOW evidence YELLOW
Development of an electrokinetic chromatography method for the rapid enantiomeric determination of 5-hydroxytryptophan. Application to the analysis of dietary supplements. ↗

PMID 41568872 ↗

Journal Analyst

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41568872/

Adu00e1mez-Rodru00edguez S et al.. Development of an electrokinetic chromatography method for the rapid enantiomeric determination of 5-hydroxytryptophan. Application to the analysis of dietary supplements.. Analyst. 2026. PMID:41568872.
Observational / other LOW evidence YELLOW
Peroxisome Proliferator-Activated Receptor u03b1 Deficiency Induces Vascular Pathologies through Endothelial Senescence in Diabetic Retinopathy. ↗

PMID 41485550 ↗

Journal Am J Pathol

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41485550/

Xu L et al.. Peroxisome Proliferator-Activated Receptor u03b1 Deficiency Induces Vascular Pathologies through Endothelial Senescence in Diabetic Retinopathy.. Am J Pathol. 2026. PMID:41485550.
Observational / other LOW evidence YELLOW
Human Recellularization for Xenoantigen-Free Decellularized Cardiac Xenografts. ↗

PMID 40836776 ↗

Journal Tissue Eng Part A

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/40836776/

Yoon JK et al.. Human Recellularization for Xenoantigen-Free Decellularized Cardiac Xenografts.. Tissue Eng Part A. 2026. PMID:40836776.
Observational / other LOW evidence YELLOW
Balancing the Cellular Inflammatory-Homeostatic Axis Through Natural Ingredient Supplementation. ↗

PMID 40871615 ↗

Journal Nutrients

Year 2025

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/40871615/

Bordano V et al.. Balancing the Cellular Inflammatory-Homeostatic Axis Through Natural Ingredient Supplementation.. Nutrients. 2025. PMID:40871615.
Observational / other LOW evidence YELLOW
Griffonia simplicifolia seeds extract rich in 5-hydroxy-L-tryptophan reduces infection and inflammation in a mouse model of vulvovaginal candidiasis. ↗

PMID 40414710 ↗

Journal J Pharm Pharmacol

Year 2025

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/40414710/

Puccetti M et al.. Griffonia simplicifolia seeds extract rich in 5-hydroxy-L-tryptophan reduces infection and inflammation in a mouse model of vulvovaginal candidiasis.. J Pharm Pharmacol. 2025. PMID:40414710.
Observational / other LOW evidence YELLOW
Deletion of Mgat2 in spermatogonia blocks spermatogenesis. ↗

PMID 39364139 ↗

Journal Front Cell Dev Biol

Year 2024

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/39364139/

Asmat MS et al.. Deletion of Mgat2 in spermatogonia blocks spermatogenesis.. Front Cell Dev Biol. 2024. PMID:39364139.
Observational / other LOW evidence YELLOW
A Rapid Total Bacterial Count Method for Food Samples using Syringe Filters and Lectin-Conjugated Semiconductor Nanorods. ↗

PMID 38785228 ↗

Journal Chem Asian J

Year 2024

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/38785228/

Sutarlie L et al.. A Rapid Total Bacterial Count Method for Food Samples using Syringe Filters and Lectin-Conjugated Semiconductor Nanorods.. Chem Asian J. 2024. PMID:38785228.
Observational / other LOW evidence YELLOW
Mode of administration influences plasma levels of active Centella asiatica compounds in 5xFAD mice while markers of neuroinflammation remain unaltered. ↗

PMID 38591068 ↗

Journal Front Neurosci

Year 2024

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/38591068/

Speers AB et al.. Mode of administration influences plasma levels of active Centella asiatica compounds in 5xFAD mice while markers of neuroinflammation remain unaltered.. Front Neurosci. 2024. PMID:38591068.

Q × L × D × S × 10 = 5.0 / 10

The GIRI Score is the product of four independently computed evidence components, each normalised to 0–1, then scaled to 0–10. Every component is derived exclusively from peer-reviewed references and regulatory data — no editorial judgement is applied.

0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.

Method: Q = number of approved references ÷ 10 (capped at 1.0)

50%

Limited — mostly case reports or animal studies

Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.

Benefit

Risk

50%

Mixed or neutral — roughly equal benefit and risk signals

Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.

50%

One or more monitoring-level safety signals active

Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.

0Q × 5L × 5D × 5S = 5.0 / 10

Final GIRI Score for Griffonia Simplicifolia. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

Full methodology & data sources

The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.

References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.

MODERATE RISK 5.0/10

Based on available regulatory signals and scientific evidence, this ingredient presents a moderate safety concern. Caution is advised, particularly at high doses or in sensitive populations.

LOW
0–3.0

MODERATE
3.0–5.5

HIGH
5.5–7.5

CRITICAL
7.5–10

5.0

The score pin shows exactly where this ingredient falls on the fixed risk scale.

What drove the Moderate classification for Griffonia Simplicifolia

A score of 5.0 places this ingredient in the Moderate band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

0 approved references.

Limited — mostly case reports or animal studies (Level 4–5).

Neutral or mixed — benefit and risk signals roughly balanced.

No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.

No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).

How are the Low / Moderate / High / Critical thresholds defined?

The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:

Level	Score	Meaning
LOW	0.0 – 2.9	Sparse or predominantly beneficial evidence. No active safety alerts.
MODERATE	3.0 – 5.4	Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups.
HIGH	5.5 – 7.4	Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended.
CRITICAL	7.5 – 10	Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision.

Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.

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Griffonia Simplicifolia

Safety Profile

Known Safety Concerns

Contraindications

Interactions

Evidence and Scientific Findings

Ingredient Overview

Biological and Chemical Classification

Mechanism of Action

Clinical Evidence of Effectiveness

Pharmacokinetics

Recommended Dosage

SETI — Scientific Evidence Transparency Index

Executive Summary — Ingredient Assessment

Evidence Summary

Evidence Policy

Evidence Distribution

Score Transparency

Risk Level Classification

What drove the Moderate classification for Griffonia Simplicifolia

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