Safety Profile
Information not yet available for this ingredient profile.
Interactions
Information not yet available for this ingredient profile.
Evidence and Scientific Findings
Ingredient Overview
Gamma-tocopherol is a Vitamin E form with distinct anti-inflammatory properties. Well tolerated at standard doses. High-dose alpha-tocopherol can displace gamma-tocopherol from tissues. May enhance anticoagulant effects of warfarin and aspirin at high doses (>400 IU equivalent). Avoid high-dose Vitamin E before surgery.
Biological and Chemical Classification
Information not yet available for this ingredient profile.
Mechanism of Action
Information not yet available for this ingredient profile.
Clinical Evidence of Effectiveness
Information not yet available for this ingredient profile.
Pharmacokinetics
Information not yet available for this ingredient profile.
Recommended Dosage
Information not yet available for this ingredient profile.
SETI — Scientific Evidence Transparency Index
Executive Summary — Ingredient Assessment
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or RCT)
- Main clinical benefit observed: Vitamins
- Evidence consistency: High consistency across studies (100%)
- No significant safety signals identified in the reviewed literature.
The available scientific evidence for Gamma-Tocopherol indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.
Total SETI Score
High risk| Evidence quality | 10/40 |
| Evidence consistency | 20/20 |
| Safety signals | 0/20 |
| Study recency | 10/10 |
| Evidence transparency | 10/10 |
Evidence Summary
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or systematic review)
- 0 studies identified benefits or no safety concern (GREEN)
- 10 studies reported limited or advisory safety evidence (YELLOW)
Evidence Policy
Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.
Last updated: 06 აპრ 2026, 12:11
Evidence Distribution
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Observational / other LOW evidence YELLOWSequential Supercritical CO(2) and Subcritical Water Extraction for the Valorisation of Pomegranate (Punica granatum L.) By-Products: A Response Surface Methodology Approach. ↗Durante M et al.. Sequential Supercritical CO(2) and Subcritical Water Extraction for the Valorisation of Pomegranate (Punica granatum L.) By-Products: A Response Surface Methodology Approach.. Plants (Basel). 2026. PMID:41901470.PMID 41901470 ↗Journal Plants (Basel)Year 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41901470/
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Observational / other LOW evidence YELLOWEffect of Addition Levels of By-Product Mixture (Apple Pomace: Red Potato Pulp: Sugar Beet Pulp) on Phytochemical Profile, Antioxidant Activity and Physical… ↗Ziobro R et al.. Effect of Addition Levels of By-Product Mixture (Apple Pomace: Red Potato Pulp: Sugar Beet Pulp) on Phytochemical Profile, Antioxidant Activity and Physical Properties of Extruded Corn Snacks.. Molecules. 2026. PMID:41900136.PMID 41900136 ↗Journal MoleculesYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41900136/
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Observational / other LOW evidence YELLOWDietary Citrus Peel Supplementation Enhances Hepatic Energy Metabolism, Muscle 9-HODE Generation and Isoleucine Catabolism in Beef Cattle. ↗Muroya S et al.. Dietary Citrus Peel Supplementation Enhances Hepatic Energy Metabolism, Muscle 9-HODE Generation and Isoleucine Catabolism in Beef Cattle.. Metabolites. 2026. PMID:41893350.PMID 41893350 ↗Journal MetabolitesYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41893350/
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Observational / other LOW evidence YELLOWSeasonal variation in meat quality of Angus steers raised in a Mediterranean forage-fed system: A farm case study. ↗Bolletta V et al.. Seasonal variation in meat quality of Angus steers raised in a Mediterranean forage-fed system: A farm case study.. PLoS One. 2026. PMID:41875090.PMID 41875090 ↗Journal PLoS OneYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41875090/
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Observational / other LOW evidence YELLOWUpcycling walnut (Juglans regia L.) by-products: characterisation of nutritionally relevant bioactive compounds. ↗Campins-Machado FM et al.. Upcycling walnut (Juglans regia L.) by-products: characterisation of nutritionally relevant bioactive compounds.. Food Funct. 2026. PMID:41873665.PMID 41873665 ↗Journal Food FunctYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41873665/
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Observational / other LOW evidence YELLOWIsothermal-microwave pretreatment enhances the quality and oxidative stability of cold-pressed oil from short-term germinated sesame seeds. ↗Zhang RY et al.. Isothermal-microwave pretreatment enhances the quality and oxidative stability of cold-pressed oil from short-term germinated sesame seeds.. Food Chem X. 2026. PMID:41847377.PMID 41847377 ↗Journal Food Chem XYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41847377/
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Observational / other LOW evidence YELLOWDietary Effects of Carotenoid-Biofortified Wheat on Feed Conversion and Tissue Antioxidant Concentrations in Broiler Chickens. ↗Szmek J et al.. Dietary Effects of Carotenoid-Biofortified Wheat on Feed Conversion and Tissue Antioxidant Concentrations in Broiler Chickens.. Foods. 2026. PMID:41829130.PMID 41829130 ↗Journal FoodsYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41829130/
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Observational / other LOW evidence YELLOWValorization of canary seeds lipid fraction and defatted flour by supercritical carbon dioxide extraction. ↗Trigueros E et al.. Valorization of canary seeds lipid fraction and defatted flour by supercritical carbon dioxide extraction.. Front Nutr. 2026. PMID:41798837.PMID 41798837 ↗Journal Front NutrYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41798837/
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Observational / other LOW evidence YELLOWConcurrent determination of fat-soluble vitamins and related compounds in plasma using HPLC with electrochemical detection. ↗Van Herreweghe M et al.. Concurrent determination of fat-soluble vitamins and related compounds in plasma using HPLC with electrochemical detection.. Anal Biochem. 2026. PMID:41796786.PMID 41796786 ↗Journal Anal BiochemYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41796786/
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Observational / other LOW evidence YELLOWAcaricidal potential and mechanistic insights of Melinis minutiflora P. Beauv. grass extracts from different cutting ages. ↗Celis Celis EM et al.. Acaricidal potential and mechanistic insights of Melinis minutiflora P. Beauv. grass extracts from different cutting ages.. Vet Parasitol. 2026. PMID:41774998.PMID 41774998 ↗Journal Vet ParasitolYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41774998/
Score Transparency
0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.
Method: Q = number of approved references ÷ 10 (capped at 1.0)
Limited — mostly case reports or animal studies
Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.
Mixed or neutral — roughly equal benefit and risk signals
Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.
One or more monitoring-level safety signals active
Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.
Final GIRI Score for Gamma-Tocopherol. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
Full methodology & data sources
The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.
- References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
- Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
- Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
- Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
Risk Level Classification
Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.
0–3.0
3.0–5.5
5.5–7.5
7.5–10
The score pin shows exactly where this ingredient falls on the fixed risk scale.
What drove the Low classification for Gamma-Tocopherol
A score of 2.0 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
0 approved references.
Limited — mostly case reports or animal studies (Level 4–5).
Neutral or mixed — benefit and risk signals roughly balanced.
No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.
No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).
How are the Low / Moderate / High / Critical thresholds defined?
The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:
| Level | Score | Meaning |
|---|---|---|
| LOW | 0.0 – 2.9 | Sparse or predominantly beneficial evidence. No active safety alerts. |
| MODERATE | 3.0 – 5.4 | Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups. |
| HIGH | 5.5 – 7.4 | Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended. |
| CRITICAL | 7.5 – 10 | Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision. |
Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.