Safety Profile
Information not yet available for this ingredient profile.
Interactions
Information not yet available for this ingredient profile.
Evidence and Scientific Findings
Ingredient Overview
Calcium caseinate is the calcium salt form of casein protein. It is a slow-digesting complete protein with a high biological value. Very well tolerated. Avoid in milk protein allergy. Provides a significant calcium contribution at high doses.
Biological and Chemical Classification
Information not yet available for this ingredient profile.
Mechanism of Action
Information not yet available for this ingredient profile.
Clinical Evidence of Effectiveness
Information not yet available for this ingredient profile.
Pharmacokinetics
Information not yet available for this ingredient profile.
Recommended Dosage
Information not yet available for this ingredient profile.
SETI — Scientific Evidence Transparency Index
Executive Summary — Ingredient Assessment
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or RCT)
- Main clinical benefit observed: Specialty
- Evidence consistency: High consistency across studies (100%)
- No significant safety signals identified in the reviewed literature.
The available scientific evidence for Calcium Caseinate indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.
Total SETI Score
High risk| Evidence quality | 10/40 |
| Evidence consistency | 20/20 |
| Safety signals | 0/20 |
| Study recency | 10/10 |
| Evidence transparency | 10/10 |
Evidence Summary
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or systematic review)
- 0 studies identified benefits or no safety concern (GREEN)
- 10 studies reported limited or advisory safety evidence (YELLOW)
Evidence Policy
Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.
Last updated: 06 აპრ 2026, 12:12
Evidence Distribution
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Observational / other LOW evidence YELLOWInfluence of Alternative Protein Sources on the Physicochemical Properties and Sensory Evaluation of a Buffalo Whey-Based Cocoa Beverage. ↗Rekowsky BSDS et al.. Influence of Alternative Protein Sources on the Physicochemical Properties and Sensory Evaluation of a Buffalo Whey-Based Cocoa Beverage.. J Food Sci. 2026. PMID:41906441.PMID 41906441 ↗Journal J Food SciYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41906441/
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Observational / other LOW evidence YELLOWThe effects of pasteurization on caseinate-based edible film solutions. ↗McAnulty MJ et al.. The effects of pasteurization on caseinate-based edible film solutions.. J Dairy Sci. 2026. PMID:41780864.PMID 41780864 ↗Journal J Dairy SciYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41780864/
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Observational / other LOW evidence YELLOWCo-gels of milk proteins and oat starch: A rheological, textural and microstructural perspective. ↗Kumar L et al.. Co-gels of milk proteins and oat starch: A rheological, textural and microstructural perspective.. Int J Biol Macromol. 2026. PMID:41558562.PMID 41558562 ↗Journal Int J Biol MacromolYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41558562/
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Observational / other LOW evidence YELLOWThe addition of plant protein to yogurt reduces the bioaccessibility of essential elements. ↗Costa-Santos AC et al.. The addition of plant protein to yogurt reduces the bioaccessibility of essential elements.. Food Res Int. 2025. PMID:41267294.PMID 41267294 ↗Journal Food Res IntYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41267294/
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Observational / other LOW evidence YELLOWExploring Biodegradable Polymeric Nanocomposite Films for Sustainable Food Packaging Application. ↗Gomez Mesa NE et al.. Exploring Biodegradable Polymeric Nanocomposite Films for Sustainable Food Packaging Application.. Polymers (Basel). 2025. PMID:40871155.PMID 40871155 ↗Journal Polymers (Basel)Year 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40871155/
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Observational / other LOW evidence YELLOWCaseinate-Carboxymethyl Chitosan Composite Edible Coating with Soybean Oil for Extending the Shelf Life of Blueberry Fruit. ↗Mohamed AMA et al.. Caseinate-Carboxymethyl Chitosan Composite Edible Coating with Soybean Oil for Extending the Shelf Life of Blueberry Fruit.. Foods. 2025. PMID:40807536.PMID 40807536 ↗Journal FoodsYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40807536/
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Observational / other LOW evidence YELLOWEffects of Zinc-Layered Filler Incorporation Routes on the Antimicrobial, Mechanical, and Physical Properties of Calcium Caseinate Biopolymeric Films. ↗Becerra ME et al.. Effects of Zinc-Layered Filler Incorporation Routes on the Antimicrobial, Mechanical, and Physical Properties of Calcium Caseinate Biopolymeric Films.. Molecules. 2025. PMID:40807484.PMID 40807484 ↗Journal MoleculesYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40807484/
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Observational / other LOW evidence YELLOWHolographic sensor for the rapid detection ofu00a0milku00a0adulteration. ↗Zhang Y et al.. Holographic sensor for the rapid detection ofu00a0milku00a0adulteration.. Appl Opt. 2025. PMID:40793746.PMID 40793746 ↗Journal Appl OptYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40793746/
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Observational / other LOW evidence YELLOWBlackseed Oil Supplemented Caseinate-Carboxymethyl Chitosan Film Membrane for Improving Shelf Life of Grape Tomato. ↗Mohamed AMA et al.. Blackseed Oil Supplemented Caseinate-Carboxymethyl Chitosan Film Membrane for Improving Shelf Life of Grape Tomato.. Materials (Basel). 2025. PMID:40508649.PMID 40508649 ↗Journal Materials (Basel)Year 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40508649/
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Observational / other LOW evidence YELLOWThe impact of sex and the cheese matrix on cholesterol metabolism in middle-aged adults. ↗Rooney M et al.. The impact of sex and the cheese matrix on cholesterol metabolism in middle-aged adults.. Atherosclerosis. 2025. PMID:39923541.PMID 39923541 ↗Journal AtherosclerosisYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/39923541/
Score Transparency
0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.
Method: Q = number of approved references ÷ 10 (capped at 1.0)
Limited — mostly case reports or animal studies
Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.
Mixed or neutral — roughly equal benefit and risk signals
Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.
One or more monitoring-level safety signals active
Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.
Final GIRI Score for Calcium Caseinate. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
Full methodology & data sources
The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.
- References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
- Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
- Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
- Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
Risk Level Classification
Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.
0–3.0
3.0–5.5
5.5–7.5
7.5–10
The score pin shows exactly where this ingredient falls on the fixed risk scale.
What drove the Low classification for Calcium Caseinate
A score of 1.0 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
0 approved references.
Limited — mostly case reports or animal studies (Level 4–5).
Neutral or mixed — benefit and risk signals roughly balanced.
No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.
No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).
How are the Low / Moderate / High / Critical thresholds defined?
The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:
| Level | Score | Meaning |
|---|---|---|
| LOW | 0.0 – 2.9 | Sparse or predominantly beneficial evidence. No active safety alerts. |
| MODERATE | 3.0 – 5.4 | Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups. |
| HIGH | 5.5 – 7.4 | Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended. |
| CRITICAL | 7.5 – 10 | Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision. |
Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.