Global Ingredient Risk Index Specialty

Brown Rice Protein

Oryza sativa

Also known as: Rice protein isolate, Brown rice protein concentrate, Plant-based protein

27 მარ 2026

LOW RISK 1.0/10 How?

This ingredient is classified as unclassified risk.

Information not yet available for this ingredient profile.

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Information not yet available for this ingredient profile.

Brown rice protein is a hypoallergenic plant-based protein source. It has an excellent safety record and is suitable for most dietary restrictions. It is lower in the essential amino acid lysine compared to whey or soy, making it less complete as a sole protein source. High rice protein intake may increase arsenic exposure from rice-based products; choose low-arsenic certified products. No significant drug interactions documented at standard supplement doses.

Scientific Name: Oryza sativa

Information not yet available for this ingredient profile.

SETI Score 50/100

Risk Level High risk

Scientific Confidence Low

Evidence Strength Limited

Key Benefit Specialty

Evidence Reviewed 10 PubMed studies

Scientific Confidence Low

Based on study quality, consistency, and recency

Executive Summary — Ingredient Assessment

SETI Score 50/100

Risk Level High risk

Evidence Strength Limited

Main Benefit Specialty

Ingredient Brown Rice Protein

Scientific name Oryza sativa

Scientific Evidence Overview

10 studies reviewed
0 high-quality studies (meta-analysis or RCT)
Main clinical benefit observed: Specialty
Evidence consistency: High consistency across studies (100%)

Safety Signals

No significant safety signals identified in the reviewed literature.

Evidence Strength Limited

Final Scientific Assessment

The available scientific evidence for Brown Rice Protein indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.

Ingredient Brown Rice Protein

Evidence reviewed 10 peer-reviewed studies (last 10 years)

Scientific name Oryza sativa

50 /100

Total SETI Score

High risk

Evidence quality	10/40
Evidence consistency	20/20
Safety signals	0/20
Study recency	10/10
Evidence transparency	10/10

Evidence Summary

10 studies reviewed
0 high-quality studies (meta-analysis or systematic review)
0 studies identified benefits or no safety concern (GREEN)
10 studies reported limited or advisory safety evidence (YELLOW)

Evidence Policy

Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.

Last updated: 06 აპრ 2026, 12:13

Evidence Distribution

10 Other / unclassified

Observational / other LOW evidence YELLOW
Metabolites with biotic and abiotic stress-alleviating effects derived from the endophytic fungus Aspergillus nishimurae associated with tissue-cultured Oryza sativa L. ↗

PMID 41937037 ↗

Journal Phytochemistry

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41937037/

Yin YW et al.. Metabolites with biotic and abiotic stress-alleviating effects derived from the endophytic fungus Aspergillus nishimurae associated with tissue-cultured Oryza sativa L.. Phytochemistry. 2026. PMID:41937037.
Observational / other LOW evidence YELLOW
The GW2-ERF115-SLRL2 module regulates seed dormancy in rice. ↗

PMID 41933699 ↗

Journal J Genet Genomics

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41933699/

Wang JD et al.. The GW2-ERF115-SLRL2 module regulates seed dormancy in rice.. J Genet Genomics. 2026. PMID:41933699.
Observational / other LOW evidence YELLOW
Two plant growth-promoting bacteria assist rice in promoting growth and reducing cadmium through different mechanisms. ↗

PMID 41931977 ↗

Journal Plant Physiol Biochem

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41931977/

Zhang Q et al.. Two plant growth-promoting bacteria assist rice in promoting growth and reducing cadmium through different mechanisms.. Plant Physiol Biochem. 2026. PMID:41931977.
Observational / other LOW evidence YELLOW
Deciphering stone mining-induced hazardous heavy metal contamination in agricultural soils using source attribution, health-dietary risk analysis, and machine learning-driven insights. ↗

PMID 41931197 ↗

Journal Environ Geochem Health

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41931197/

Acharya A et al.. Deciphering stone mining-induced hazardous heavy metal contamination in agricultural soils using source attribution, health-dietary risk analysis, and machine learning-driven insights.. Environ Geochem Health. 2026. PMID:41931197.
Observational / other LOW evidence YELLOW
CRISPR/Cas9 Editing of the Wheat Iron Sensor TaHRZ1 Confirms Its Conserved Role in Iron Homeostasis and Allocation in Grains. ↗

PMID 41930411 ↗

Journal Plant Cell Environ

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41930411/

Tyagi DS et al.. CRISPR/Cas9 Editing of the Wheat Iron Sensor TaHRZ1 Confirms Its Conserved Role in Iron Homeostasis and Allocation in Grains.. Plant Cell Environ. 2026. PMID:41930411.
Observational / other LOW evidence YELLOW
Genome-wide identification and characterization of WOX gene family in saffron (Crocus sativus L.) and their roles in stress response, development and callus… ↗

PMID 41929833 ↗

Journal Front Plant Sci

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41929833/

Tao Y et al.. Genome-wide identification and characterization of WOX gene family in saffron (Crocus sativus L.) and their roles in stress response, development and callus formation.. Front Plant Sci. 2026. PMID:41929833.
Observational / other LOW evidence YELLOW
Allele-informed QTL-seq identifies Hd18 as a minor modifier of heading date in elite rice cultivars. ↗

PMID 41923186 ↗

Journal Plant Genome

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41923186/

Lee H et al.. Allele-informed QTL-seq identifies Hd18 as a minor modifier of heading date in elite rice cultivars.. Plant Genome. 2026. PMID:41923186.
Observational / other LOW evidence YELLOW
Differential Activity of Enantiopure R- and S-Flusulfinam in Rice (Oryza sativa L.) and Barnyard Grass (Echinochloa crus-galli): Evidence from Metabolite Fingerprinting and… ↗

PMID 41919467 ↗

Journal J Agric Food Chem

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41919467/

Luo Y et al.. Differential Activity of Enantiopure R- and S-Flusulfinam in Rice (Oryza sativa L.) and Barnyard Grass (Echinochloa crus-galli): Evidence from Metabolite Fingerprinting and Metabolomics.. J Agric Food Chem. 2026. PMID:41919467.
Observational / other LOW evidence YELLOW
Multi-omics Analysis Reveals the Hormonal Basis of Differential Response to Nighttime Heat Temperature Between Superior and Inferior Rice Grains. ↗

PMID 41915269 ↗

Journal Rice (N Y)

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41915269/

Fang H et al.. Multi-omics Analysis Reveals the Hormonal Basis of Differential Response to Nighttime Heat Temperature Between Superior and Inferior Rice Grains.. Rice (N Y). 2026. PMID:41915269.
Observational / other LOW evidence YELLOW
The Transcription Factor OsWRKY64 Interacts With OsART1 to Positively Regulate Al Resistance in Rice. ↗

PMID 41914025 ↗

Journal Plant Biotechnol J

Year 2026

Study type Observational / other

Evidence strength LOW evidence

PubMed link https://pubmed.ncbi.nlm.nih.gov/41914025/

Chen C et al.. The Transcription Factor OsWRKY64 Interacts With OsART1 to Positively Regulate Al Resistance in Rice.. Plant Biotechnol J. 2026. PMID:41914025.

Q × L × D × S × 10 = 1.0 / 10

The GIRI Score is the product of four independently computed evidence components, each normalised to 0–1, then scaled to 0–10. Every component is derived exclusively from peer-reviewed references and regulatory data — no editorial judgement is applied.

0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.

Method: Q = number of approved references ÷ 10 (capped at 1.0)

50%

Limited — mostly case reports or animal studies

Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.

Benefit

Risk

50%

Mixed or neutral — roughly equal benefit and risk signals

Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.

50%

One or more monitoring-level safety signals active

Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.

0Q × 5L × 5D × 5S = 1.0 / 10

Final GIRI Score for Brown Rice Protein. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

Full methodology & data sources

The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.

References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.

LOW RISK 1.0/10

Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.

LOW
0–3.0

MODERATE
3.0–5.5

HIGH
5.5–7.5

CRITICAL
7.5–10

1.0

The score pin shows exactly where this ingredient falls on the fixed risk scale.

What drove the Low classification for Brown Rice Protein

A score of 1.0 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.

0 approved references.

Limited — mostly case reports or animal studies (Level 4–5).

Neutral or mixed — benefit and risk signals roughly balanced.

No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.

No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).

How are the Low / Moderate / High / Critical thresholds defined?

The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:

Level	Score	Meaning
LOW	0.0 – 2.9	Sparse or predominantly beneficial evidence. No active safety alerts.
MODERATE	3.0 – 5.4	Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups.
HIGH	5.5 – 7.4	Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended.
CRITICAL	7.5 – 10	Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision.

Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.

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Brown Rice Protein

Safety Profile

Interactions

Evidence and Scientific Findings

Ingredient Overview

Biological and Chemical Classification

Mechanism of Action

Clinical Evidence of Effectiveness

Pharmacokinetics

Recommended Dosage

SETI — Scientific Evidence Transparency Index

Executive Summary — Ingredient Assessment

Evidence Summary

Evidence Policy

Evidence Distribution

Score Transparency

Risk Level Classification

What drove the Low classification for Brown Rice Protein

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