Aquamin® Mg (Marine Magnesium)
Lithothamnion spp. (red marine algae)
Also known as: Aquamin Mg, Marine magnesium, Lithothamnion magnesium, Seaweed magnesium, Red algae magnesium, Aquamin marine minerals
This ingredient is classified as unclassified risk (GIRI score: 1.5/10).
Safety Profile
Known Safety Concerns
- Diarrhoea at high doses (EFSA UL 350 mg elemental Mg/day from supplements); caution in renal insufficiency; chelates fluoroquinolone/tetracycline antibiotics
Contraindications
- Diarrhoea at high doses (EFSA UL 350 mg elemental Mg/day from supplements); caution in renal insufficiency; chelates fluoroquinolone/tetracycline antibiotics
Interactions
Information not yet available for this ingredient profile.
Evidence and Scientific Findings
Ingredient Overview
Aquamin® Mg is a branded marine-derived magnesium ingredient produced by Marigot Ltd (Ireland) from sustainably harvested red marine algae (Lithothamnion calcareum and Lithothamnion corallioides — Corallinaceae family) sourced from the North Atlantic Ocean (primarily Iceland and Ireland). Aquamin® provides magnesium in a naturally occurring multi-mineral matrix with calcium, magnesium, and 72+ trace marine minerals including zinc, boron, and selenium. Magnesium content: ~12% elemental magnesium per gram of Aquamin Mg. Bioavailability is comparable to conventional magnesium salts (citrate, oxide). Magnesium functions: ATP synthesis (required for >300 enzymatic reactions); protein synthesis; muscle and nerve function; cardiac rhythm; blood pressure regulation; bone mineral density; insulin sensitivity; sleep quality (GABA modulation). Clinical applications: muscle cramp prevention; exercise recovery; electrolyte balance; sleep. Generally very well tolerated — excess magnesium is renally excreted. High doses (>350 mg elemental Mg from supplements, per EFSA UL) may cause osmotic diarrhoea (laxative effect) — the most common side effect. Caution in renal insufficiency (impaired magnesium excretion — risk of hypermagnesaemia). Drug interactions: magnesium chelates fluoroquinolone and tetracycline antibiotics (take 2 hours apart); may enhance antihypertensive effects; bisphosphonate absorption reduced (take 2 hours apart). Aquamin® branded — document as distinct from standard magnesium salts in GIRI.
Biological and Chemical Classification
- Scientific Name
- Lithothamnion spp. (red marine algae)
Mechanism of Action
Information not yet available for this ingredient profile.
Clinical Evidence of Effectiveness
Information not yet available for this ingredient profile.
Pharmacokinetics
Information not yet available for this ingredient profile.
Recommended Dosage
Information not yet available for this ingredient profile.
SETI — Scientific Evidence Transparency Index
Evidence unavailable.
No peer-reviewed studies with traceable links have been retrieved for this ingredient. Use the button below to fetch evidence from PubMed.
Score Transparency
0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.
Method: Q = number of approved references ÷ 10 (capped at 1.0)
Limited — mostly case reports or animal studies
Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.
Mixed or neutral — roughly equal benefit and risk signals
Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.
One or more monitoring-level safety signals active
Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.
Final GIRI Score for Aquamin® Mg (Marine Magnesium). Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
Full methodology & data sources
The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.
- References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
- Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
- Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
- Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
Risk Level Classification
Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.
0–3.0
3.0–5.5
5.5–7.5
7.5–10
The score pin shows exactly where this ingredient falls on the fixed risk scale.
What drove the Low classification for Aquamin® Mg (Marine Magnesium)
A score of 1.5 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
0 approved references.
Limited — mostly case reports or animal studies (Level 4–5).
Neutral or mixed — benefit and risk signals roughly balanced.
No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.
No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).
How are the Low / Moderate / High / Critical thresholds defined?
The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:
| Level | Score | Meaning |
|---|---|---|
| LOW | 0.0 – 2.9 | Sparse or predominantly beneficial evidence. No active safety alerts. |
| MODERATE | 3.0 – 5.4 | Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups. |
| HIGH | 5.5 – 7.4 | Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended. |
| CRITICAL | 7.5 – 10 | Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision. |
Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.