Safety Profile
Information not yet available for this ingredient profile.
Interactions
Information not yet available for this ingredient profile.
Evidence and Scientific Findings
Ingredient Overview
Red raspberry fruit extract is used for antioxidant effects and in weight loss products as raspberry ketones. The berry extract is very safe. Raspberry ketone supplements lack clinical safety data at supplemental doses and may have stimulant effects. The berry extract itself has an excellent safety record with no significant drug interactions.
Biological and Chemical Classification
- Scientific Name
- Rubus idaeus
Mechanism of Action
Information not yet available for this ingredient profile.
Clinical Evidence of Effectiveness
Information not yet available for this ingredient profile.
Pharmacokinetics
Information not yet available for this ingredient profile.
Recommended Dosage
Information not yet available for this ingredient profile.
SETI — Scientific Evidence Transparency Index
Executive Summary — Ingredient Assessment
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or RCT)
- Main clinical benefit observed: Botanical
- Evidence consistency: High consistency across studies (100%)
- No significant safety signals identified in the reviewed literature.
The available scientific evidence for Red Raspberry Fruit Extract indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.
Total SETI Score
High risk| Evidence quality | 10/40 |
| Evidence consistency | 20/20 |
| Safety signals | 0/20 |
| Study recency | 10/10 |
| Evidence transparency | 10/10 |
Evidence Summary
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or systematic review)
- 0 studies identified benefits or no safety concern (GREEN)
- 10 studies reported limited or advisory safety evidence (YELLOW)
Evidence Policy
Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.
Last updated: 26 მარ 2026, 14:37
Evidence Distribution
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Observational / other LOW evidence YELLOWThe origin of the octoploid cloudberry (Rubus chamaemorus) genome is the result of multiple and complex polyploidization events. ↗Strand MA et al.. The origin of the octoploid cloudberry (Rubus chamaemorus) genome is the result of multiple and complex polyploidization events.. J Hered. 2026. PMID:41879285.PMID 41879285 ↗Journal J HeredYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41879285/
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Observational / other LOW evidence YELLOWDevelopment of a Flex-Seq SNP panel for raspberry (Rubus idaeus L.) and validation through linkage map construction and identification of QTL for… ↗Davik J et al.. Development of a Flex-Seq SNP panel for raspberry (Rubus idaeus L.) and validation through linkage map construction and identification of QTL for several traits of agronomic importance to raspberry breeding.. PLoS One. 2026. PMID:41701706.PMID 41701706 ↗Journal PLoS OneYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41701706/
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Observational / other LOW evidence YELLOWActive Polysaccharide Films Incorporating Cannabis sativa Flower Extract for Extending the Shelf Life of Freeze-Dried Berries. ↗Dobrucka R et al.. Active Polysaccharide Films Incorporating Cannabis sativa Flower Extract for Extending the Shelf Life of Freeze-Dried Berries.. Molecules. 2026. PMID:41683420.PMID 41683420 ↗Journal MoleculesYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41683420/
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Observational / other LOW evidence YELLOWBeyond prescription medicine in pregnancy - raspberry leaf and other herbs in Australia. ↗Bowman RL et al.. Beyond prescription medicine in pregnancy - raspberry leaf and other herbs in Australia.. BMC Complement Med Ther. 2026. PMID:41668030.PMID 41668030 ↗Journal BMC Complement Med TherYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41668030/
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Observational / other LOW evidence YELLOWRaspberry protective role in inflammatory diseases: An overview. ↗Arya P et al.. Raspberry protective role in inflammatory diseases: An overview.. Iran J Basic Med Sci. 2026. PMID:41641148.PMID 41641148 ↗Journal Iran J Basic Med SciYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41641148/
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Observational / other LOW evidence YELLOWRed raspberry improves postprandial metabolic indices and cognitive function in older adults who are overweight or have obesity. ↗Xiao D et al.. Red raspberry improves postprandial metabolic indices and cognitive function in older adults who are overweight or have obesity.. Br J Nutr. 2026. PMID:41536265.PMID 41536265 ↗Journal Br J NutrYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41536265/
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Observational / other LOW evidence YELLOWEllagitannins from red raspberry (Rubus idaeus L.): a comprehensive review on chemistry characteristics and beneficial effects. ↗Tao M et al.. Ellagitannins from red raspberry (Rubus idaeus L.): a comprehensive review on chemistry characteristics and beneficial effects.. Food Funct. 2026. PMID:41527457.PMID 41527457 ↗Journal Food FunctYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41527457/
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Observational / other LOW evidence YELLOWInfluence of u03b2-Cyclodextrin on the Overall Antioxidant Activity and DPPHu00b7 Reaction Kinetics of Fresh Raspberry (Rubus idaeus L.) and Dehydrated Strawberry (Fragaria… ↗Fiu0163oiu Voin M et al.. Influence of u03b2-Cyclodextrin on the Overall Antioxidant Activity and DPPHu00b7 Reaction Kinetics of Fresh Raspberry (Rubus idaeus L.) and Dehydrated Strawberry (Fragaria u00d7 ananassa Duch.) Extracts.. Plants (Basel). 2026. PMID:41515097.PMID 41515097 ↗Journal Plants (Basel)Year 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41515097/
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Observational / other LOW evidence YELLOWBioproduction of raspberry ketone using Phyllostachys bamboo cells expressing raspberry ketone biosynthetic genes. ↗Koeduka T et al.. Bioproduction of raspberry ketone using Phyllostachys bamboo cells expressing raspberry ketone biosynthetic genes.. Plant Biotechnol (Tokyo). 2025. PMID:41523589.PMID 41523589 ↗Journal Plant Biotechnol (Tokyo)Year 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41523589/
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Observational / other LOW evidence YELLOWPhysicochemical Properties of Berry Seeds Recovered from Pomace and Their Potential Applications in Food and Cosmetic Industries. ↗Kieu0142tyka-Dadasiewicz A et al.. Physicochemical Properties of Berry Seeds Recovered from Pomace and Their Potential Applications in Food and Cosmetic Industries.. Int J Mol Sci. 2025. PMID:41515920.PMID 41515920 ↗Journal Int J Mol SciYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41515920/
Score Transparency
0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.
Method: Q = number of approved references ÷ 10 (capped at 1.0)
Limited — mostly case reports or animal studies
Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.
Mixed or neutral — roughly equal benefit and risk signals
Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.
One or more monitoring-level safety signals active
Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.
Final GIRI Score for Red Raspberry Fruit Extract. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
Full methodology & data sources
The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.
- References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
- Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
- Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
- Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
Risk Level Classification
Based on available regulatory signals and scientific evidence, this ingredient presents a low safety concern under normal conditions of use.
0–3.0
3.0–5.5
5.5–7.5
7.5–10
The score pin shows exactly where this ingredient falls on the fixed risk scale.
What drove the Low classification for Red Raspberry Fruit Extract
A score of 1.5 places this ingredient in the Low band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
0 approved references.
Limited — mostly case reports or animal studies (Level 4–5).
Neutral or mixed — benefit and risk signals roughly balanced.
No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.
No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).
How are the Low / Moderate / High / Critical thresholds defined?
The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:
| Level | Score | Meaning |
|---|---|---|
| LOW | 0.0 – 2.9 | Sparse or predominantly beneficial evidence. No active safety alerts. |
| MODERATE | 3.0 – 5.4 | Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups. |
| HIGH | 5.5 – 7.4 | Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended. |
| CRITICAL | 7.5 – 10 | Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision. |
Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.