Green Coffee Extract
Coffea arabica (unroasted)
Also known as: Green coffee bean extract, Unroasted Coffea arabica extract, Chlorogenic acid complex, CGA extract, GCBE
This ingredient is classified as unclassified risk (GIRI score: 3.5/10).
Safety Profile
Known Safety Concerns
- Caffeine load (CYP1A2 interactions); dual-stimulant risk when combined with Guarana; caution in hypertension and cardiac arrhythmia
Contraindications
- Caffeine load (CYP1A2 interactions); dual-stimulant risk when combined with Guarana; caution in hypertension and cardiac arrhythmia
Interactions
Information not yet available for this ingredient profile.
Evidence and Scientific Findings
Ingredient Overview
Green coffee extract (GCBE) is derived from unroasted Coffea arabica beans, standardised for chlorogenic acids (CGA; typically 45–50%). Roasting destroys most CGA, so GCBE provides substantially higher CGA content than standard coffee. CGA inhibits intestinal SGLT1 glucose transporter, reducing post-prandial glucose absorption; also has antioxidant, mild anti-inflammatory, and modest thermogenic activity. Meta-analyses show ~1.5–3 kg weight reduction vs placebo over 8–12 weeks. Contains residual caffeine (~10–20 mg per extract dose in typical supplement serving). Caffeine content from GCBE adds to total caffeine load — critical when combined with Guarana (dual caffeine source). Drug interactions: caffeine is a CYP1A2 substrate — interactions with fluoroquinolone antibiotics (ciprofloxacin), fluvoxamine, theophylline, clozapine (caffeine levels elevated); additive effect with other stimulants. Caution in hypertension, cardiac arrhythmia, anxiety disorders. Avoid in pregnancy and nursing. At doses providing >400 mg caffeine/day (combined sources), risk of tachycardia, insomnia, anxiety.
Biological and Chemical Classification
- Scientific Name
- Coffea arabica (unroasted)
Mechanism of Action
Information not yet available for this ingredient profile.
Clinical Evidence of Effectiveness
Information not yet available for this ingredient profile.
Pharmacokinetics
Information not yet available for this ingredient profile.
Recommended Dosage
Information not yet available for this ingredient profile.
SETI — Scientific Evidence Transparency Index
Executive Summary — Ingredient Assessment
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or RCT)
- Main clinical benefit observed: Botanical
- Evidence consistency: High consistency across studies (100%)
- Caffeine load (CYP1A2 interactions); dual-stimulant risk when combined with Guarana; caution in hypertension and cardiac arrhythmia
The available scientific evidence for Green Coffee Extract indicates notable safety signals that warrant caution. Use should be considered carefully and monitored, particularly in sensitive populations or alongside other medications.
Total SETI Score
High risk| Evidence quality | 10/40 |
| Evidence consistency | 20/20 |
| Safety signals | 0/20 |
| Study recency | 10/10 |
| Evidence transparency | 10/10 |
Evidence Summary
- 10 studies reviewed
- 0 high-quality studies (meta-analysis or systematic review)
- 0 studies identified benefits or no safety concern (GREEN)
- 10 studies reported limited or advisory safety evidence (YELLOW)
Evidence Policy
Only peer-reviewed scientific literature indexed in PubMed or comparable databases is included in this evaluation. Commercial websites, blogs, and marketing materials are excluded. All references include direct traceable links to source documents.
Last updated: 06 აპრ 2026, 12:09
Evidence Distribution
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Observational / other LOW evidence YELLOWStructural Insights and Metabolic Profiles of Oxidized Green Coffee Extract, and Its Impact on Obesity and Gut Microbiota in High-Fat Diet-Fed Mice. ↗He J et al.. Structural Insights and Metabolic Profiles of Oxidized Green Coffee Extract, and Its Impact on Obesity and Gut Microbiota in High-Fat Diet-Fed Mice.. Nutrients. 2026. PMID:41754155.PMID 41754155 ↗Journal NutrientsYear 2026Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41754155/
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Observational / other LOW evidence YELLOWPolymer-lipid hybrid nanoparticles incorporating green coffee extract: enhancing treatment for hepatic steatosis and fibrosis through metabolomic insights. ↗Uriostegui-Campos MA et al.. Polymer-lipid hybrid nanoparticles incorporating green coffee extract: enhancing treatment for hepatic steatosis and fibrosis through metabolomic insights.. RSC Adv. 2025. PMID:41323711.PMID 41323711 ↗Journal RSC AdvYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41323711/
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Observational / other LOW evidence YELLOWSystematic Review of the Effects of Plant-Based Foods on Metabolic Outcomes in Adults with MASLD and Comorbidities Such as Obesity, Metabolic Syndrome,… ↗Jurek JM et al.. Systematic Review of the Effects of Plant-Based Foods on Metabolic Outcomes in Adults with MASLD and Comorbidities Such as Obesity, Metabolic Syndrome, and Type 2 Diabetes.. Nutrients. 2025. PMID:41010543.PMID 41010543 ↗Journal NutrientsYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/41010543/
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Observational / other LOW evidence YELLOWCoffea arabica Extracts and Metabolites with Potential Inhibitory Activity of the Major Enzymes in Bothrops asper Venom. ↗Pu00e1ez E et al.. Coffea arabica Extracts and Metabolites with Potential Inhibitory Activity of the Major Enzymes in Bothrops asper Venom.. Pharmaceuticals (Basel). 2025. PMID:40872542.PMID 40872542 ↗Journal Pharmaceuticals (Basel)Year 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40872542/
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Observational / other LOW evidence YELLOWEffect of aqueous green coffee extract (Coffea canephora) on the intestinal health of Wistar rats fed with a hypercaloric and hyperlipidic diet. ↗Meneguelli NAS et al.. Effect of aqueous green coffee extract (Coffea canephora) on the intestinal health of Wistar rats fed with a hypercaloric and hyperlipidic diet.. Food Funct. 2025. PMID:40879272.PMID 40879272 ↗Journal Food FunctYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40879272/
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Observational / other LOW evidence YELLOWGreen Coffee Extract (Coffea canephora) Administered as Treatment Modulates Hepatic Markers and Attenuates Hepatic Steatosis in Rats Fed a High-Fat Diet. ↗Domiciano do Nascimento M et al.. Green Coffee Extract (Coffea canephora) Administered as Treatment Modulates Hepatic Markers and Attenuates Hepatic Steatosis in Rats Fed a High-Fat Diet.. Mol Nutr Food Res. 2025. PMID:40631586.PMID 40631586 ↗Journal Mol Nutr Food ResYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40631586/
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Observational / other LOW evidence YELLOWIn vitro and In silico Assessment of the Antiviral Potential of Green Tea, Green Coffee, Pomegranate Peel, and Orange Peel. ↗Mokhtar NS et al.. In vitro and In silico Assessment of the Antiviral Potential of Green Tea, Green Coffee, Pomegranate Peel, and Orange Peel.. Recent Adv Antiinfect Drug Discov. 2025. PMID:40356390.PMID 40356390 ↗Journal Recent Adv Antiinfect Drug DiscovYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40356390/
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Observational / other LOW evidence YELLOWComposition of Coffee Beans Influenced by Bioprocessing with Selected Bacteria. ↗Pakosz P et al.. Composition of Coffee Beans Influenced by Bioprocessing with Selected Bacteria.. Foods. 2025. PMID:40238280.PMID 40238280 ↗Journal FoodsYear 2025Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/40238280/
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Observational / other LOW evidence YELLOWAtherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment. ↗Prasad K. Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment.. Int J Angiol. 2024. PMID:39502352.PMID 39502352 ↗Journal Int J AngiolYear 2024Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/39502352/
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Observational / other LOW evidence YELLOWEffectiveness of a combination of laccase and green coffee extract on oral malodor: a comparative, randomized, controlled, evaluator-blind, parallel-group trial. ↗Santos SL et al.. Effectiveness of a combination of laccase and green coffee extract on oral malodor: a comparative, randomized, controlled, evaluator-blind, parallel-group trial.. J Breath Res. 2024. PMID:39496199.PMID 39496199 ↗Journal J Breath ResYear 2024Study type Observational / otherEvidence strength LOW evidencePubMed link https://pubmed.ncbi.nlm.nih.gov/39496199/
Score Transparency
0 of 10 approved references (score saturates at 10). More peer-reviewed studies = stronger evidence base.
Method: Q = number of approved references ÷ 10 (capped at 1.0)
Limited — mostly case reports or animal studies
Method: L = mean study-level weight across approved references. Level 1 (meta-analysis / systematic review) = 1.0; Level 2 (RCT) = 0.8; Level 3 (cohort/case-control) = 0.6; Level 4 (case report) = 0.4; Level 5 (animal / in-vitro) = 0.2.
Mixed or neutral — roughly equal benefit and risk signals
Method: D = (sum of risk-scored references − sum of benefit-scored references) ÷ total evidence score, then scaled from [−1, 1] to [0, 1]. 0.0 = pure benefit; 0.5 = neutral; 1.0 = pure risk.
One or more monitoring-level safety signals active
Method: S = 0.5 (neutral baseline) + sum of active signal severity deltas ÷ 10. Severity deltas: Critical = +2.0, High = +1.5, Moderate = +1.0, Low = +0.5. Capped at 1.0.
Final GIRI Score for Green Coffee Extract. Risk level thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
Full methodology & data sources
The GIRI Score is computed entirely from structured data — no editorial scoring or subjective weighting is applied at any step.
- References: Only approved references are counted. Each reference is assigned an evidence level (L1–L5) and a direction (risk / neutral / benefit) by the reference manager or AI classifier.
- Safety Signals: Sourced from regulatory agencies (FDA, EMA, Health Canada, TGA, and others) and pharmacovigilance databases. Only active signals count toward the score.
- Formula version: GIRI Score v3.7.0 — Q × L × D × S × 10.
- Limitations: The score reflects published evidence and recorded signals as of the last update date. It is not a clinical risk assessment and should not replace advice from a qualified healthcare professional.
Risk Level Classification
Based on available regulatory signals and scientific evidence, this ingredient presents a moderate safety concern. Caution is advised, particularly at high doses or in sensitive populations.
0–3.0
3.0–5.5
5.5–7.5
7.5–10
The score pin shows exactly where this ingredient falls on the fixed risk scale.
What drove the Moderate classification for Green Coffee Extract
A score of 3.5 places this ingredient in the Moderate band. Thresholds: Low 0–3.0 · Moderate 3.0–5.5 · High 5.5–7.5 · Critical 7.5–10.
0 approved references.
Limited — mostly case reports or animal studies (Level 4–5).
Neutral or mixed — benefit and risk signals roughly balanced.
No active signals — S component is at neutral baseline (0.5), contributing no extra risk weight.
No major regulatory restrictions or advisories recorded across monitored jurisdictions (FDA, EMA, Health Canada, TGA, and others).
How are the Low / Moderate / High / Critical thresholds defined?
The four risk levels are fixed score bands. A score is assigned to exactly one level based on where it falls:
| Level | Score | Meaning |
|---|---|---|
| LOW | 0.0 – 2.9 | Sparse or predominantly beneficial evidence. No active safety alerts. |
| MODERATE | 3.0 – 5.4 | Mixed signals — some risk alongside benefit. Caution at high doses or in sensitive groups. |
| HIGH | 5.5 – 7.4 | Multiple studies or regulatory alerts documenting adverse effects. Professional oversight recommended. |
| CRITICAL | 7.5 – 10 | Regulatory restrictions in one or more major jurisdictions. Serious documented harm. Avoid without specialist supervision. |
Thresholds are fixed constants (GIRI_Score_Utils::LEVEL_THRESHOLDS). They do not change per ingredient and are never subject to editorial adjustment.